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Article
Open AccessNintedanib administration after the onset of acute exacerbation of interstitial lung disease in the real world
Nintedanib reduces the decline in forced vital capacity and extends the time to the first acute exacerbation of interstitial lung disease (AE-ILD). However, the effect of additional nintedanib administration a...
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Article
Open AccessThe synergetic effect of sitafloxacin–arbekacin combination in the Mycobacterium abscessus species
Mycobacterium abscessus species (MABS) is the most commonly isolated rapidly growing mycobacteria (RGM) and is one of the most antibiotic-resistant RGM with rapid progression, therefore, treatment of MABS is stil...
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Article
Open AccessHigh lymphocyte population-related predictive factors for a long-term response in non-small cell lung cancer patients treated with pemetrexed: a retrospective observational study
Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squam...
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Article
Open AccessThe synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex
Nontuberculous mycobacteria (NTM) are ubiquitous organisms and the incidence of NTM infections has been increasing in recent years. Mycobacteroides abscessus (M. abscessus) is one of the most antimicrobial-resist...
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Article
Open AccessPirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1
Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1...
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Article
Open AccessCancer cell migration on elongate protrusions of fibroblasts in collagen matrix
Cancer-associated fibroblasts (CAFs) play critical roles in the tumor progression. However, it remains unclear how cancer cells migrate in the three-dimensional (3D) matrix of cancer tissues and how CAFs suppo...
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Article
Open AccessAnalysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study
Liquid biopsy approaches, such as measuring circulating tumour cells (CTCs), have recently been introduced in several clinical studies. However, the development of CTCs as a predictive marker for treatment eff...
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Article
Open AccessCombination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes
Airway fibrosis is one of the pathological features of chronic obstructive pulmonary disease (COPD), and recent studies revealed that acetylcholine plays an important role in the development of airway remodeli...
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Article
Open AccessLung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis: a case report and literature review
Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels ...
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Association of COPD and Lung Cancer: How Does COPD Management Change the Outcome of Treatment of Lung Cancer?
Chronic obstructive pulmonary disease (COPD) and lung cancer are caused by cigarette smoking, and there is increasing evidence linking the two diseases beyond a common etiology. COPD is widely considered to be...
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Article
Open AccessDifferentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type I collagen gel cultures
Fibroblasts are heterogeneous mesenchymal cells that play important roles in the production and maintenance of extracellular matrix. Although their heterogeneity is recognized, progenitor progeny relationships...
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Article
Open AccessNF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract
We have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial cells (HBECs), and that IL-6/STAT3 signal...
