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Article
Long-term endoscopic change of gastric polyp associated with administration of vonoprazan
Vonoprazan (VPZ) has been available in Japan since 2015. Endoscopic features of proton-pump inhibitor (PPI)-related gastric mucosal changes, including fundic gland and hyperplastic polyps, have been observed. ...
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Article
Open AccessRab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy
Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial infection in xenophagy is...
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Article
Open AccessProteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins
The molecular pathology of diffuse large B cell lymphoma (DLBCL) has been extensively studied. Among DLBCL subtypes, the prognosis of CD5-positive DLBCL is worse than that of CD5-negative DLBCL, considering th...
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Article
Clinical predictors of cardiac syncope in patients with unexplained syncope after the implantation of an insertable cardiac monitor
Syncope prognosis is related to both its etiology and comorbidities, with cardiac syncope (CS) having higher risks for mortality and cardiovascular events than syncope of non-cardiac causes. Although a novel i...
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Article
Open AccessIntegrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) afflicts a significant percentage of the population; however, no effective treatments have yet been established because of the unsuitability of in vitro assays and ani...
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Article
Open AccessPharmacist perceptions of a “good death” and differences in perception between patients with cancer, oncologists, and oncology nurses: a questionnaire survey
For pharmacists expected to encounter the deaths of many of their patients in the near future, it is important to understand the perception of a “good death” for patients with cancer who are likely to be aware...
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Article
Open AccessILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells
DNA cytosine deaminase APOBEC3B (A3B) is an endogenous source of mutations in many human cancers, including multiple myeloma. A3B proteins form catalytically inactive high molecular mass (HMM) complexes in nuc...
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Article
Clioquinol kills astrocyte-derived KT-5 cells by the impairment of the autophagy–lysosome pathway
Clioquinol has been implicated as a causative agent for subacute myelo-optico-neuropathy (SMON) in humans, although the mechanism remains to be elucidated. In this study, we utilized astrocyte-derived cell lin...
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Article
Open AccessLewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases
Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clin...
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Article
Open AccessLionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload
Recent high-throughput approaches have revealed a vast number of transcripts with unknown functions. Many of these transcripts are long noncoding RNAs (lncRNAs), and intergenic region-derived lncRNAs are class...
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Article
Open AccessThe Ratios of monounsaturated to saturated phosphatidylcholines in lung adenocarcinoma microenvironment analyzed by Liquid Chromatography-Mass spectrometry and imaging Mass spectrometry
Adenocarcinoma is the most common type of lung cancer, and can be classified into various histologic subtypes. However, little is known about the subtype-dependent variations in lipid metabolism processes. We ...
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Article
Monitoring of fatigue in radiologists during prolonged image interpretation using fNIRS
To determine whether functional near-infrared spectroscopy (fNIRS) allows monitoring fatigue in radiologists during prolonged image interpretation.
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Article
Open AccessAnti-Hexokinase 1 Antibody as a Novel Serum Biomarker of a Subgroup of Diabetic Macular Edema
Diabetic retinopathy (DR) induces the breakdown of the blood-retinal barrier and promotes neuroinflammation, although autoimmune responses to sequestered retinal antigens remain poorly understood. In this stud...
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Article
Anti-fumarase antibody promotes the dropout of photoreceptor inner and outer segments in diabetic macular oedema
In diabetic macular oedema (DMO), blood components passing through the disrupted blood–retinal barrier cause neuroinflammation, but the mechanism by which autoantibodies induce neuroglial dysfunction is unknow...
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Article
Reliability of diagnosing acute ischemic cerebrovascular on magnetic resonance imaging disorders using iPads
The use of tablet terminals has been explored in various medical settings; however, caution should be exercised when performing image diagnosis using this technology. The present study examined the characteris...
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Article
Open AccessHepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction
Acute cardiac rupture and adverse left ventricular (LV) remodeling causing heart failure are serious complications of acute myocardial infarction (MI). While cardio-hepatic interactions have been recognized, t...
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Article
Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer
To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ...
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Article
Open AccessStable polefinding and rational least-squares fitting via eigenvalues
A common way of finding the poles of a meromorphic function f in a domain, where an explicit expression of f is unknown but f can be evaluated at any given z, is to interpolate f by a rational function ...
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Article
Open AccessDiagnostic performance of 18F-FDG PET/CT and whole-body diffusion-weighted imaging with background body suppression (DWIBS) in detection of lymph node and bone metastases from pediatric neuroblastoma
Recent many studies have shown that whole body “diffusion-weighted imaging with background body signal suppression” (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing ra...
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Article
Open AccessIncrease of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease in which dysregulation of B cells has been recognized. Here, we searched for potential biomarkers of SLE using liquid chromatography-tand...
