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Article
Open AccessMorphometrics in three dimensional choroidal vessel models constructed from swept-source optical coherence tomography images
We created three types of vessel models: vessel volume, surface, and line models from swept-source optical coherence tomography images and tested experimentally calculated three-dimensional (3D) biomarkers. Th...
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Article
Open AccessTAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress
Ribonucleotide reductase (RNR) is composed of two non-identical subunits, R1 and R2, and plays a crucial role in balancing the cellular dNTP pool, establishing it as an attractive cancer target. Herein, we rep...
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Article
Validity of the Algorithm for Liver Resection of Hepatocellular Carcinoma in the Caudate Lobe
We aimed to validate our algorithm for resecting Hepatocellular carcinoma (HCC) in the caudate lobe based on tumor location, tumor size, and indocyanine green clearance rate.
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Article
Open AccessArtificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease
Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets f...
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Article
Open AccessSemantic Segmentation of the Choroid in Swept Source Optical Coherence Tomography Images for Volumetrics
The choroid is a complex vascular tissue that is covered with the retinal pigment epithelium. Ultra high speed swept source optical coherence tomography (SS-OCT) provides us with high-resolution cube scan imag...
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Article
Liver Resection Versus Embolization for Recurrent Hepatocellular Carcinoma
Despite curative resection, hepatocellular carcinoma (HCC) has a high probability of recurrence. We validated the potential role of liver resection (LR) for recurrent HCC.
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Article
Prediction of esophageal varices by liver and spleen MR elastography
We aimed to assess the diagnostic performance of MR elastography (MRE) in predicting esophageal varices (EVs) in patients with chronic liver disease.
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Article
Open AccessA prediction model for the grade of liver fibrosis using magnetic resonance elastography
Liver stiffness measurement (LSM) has recently become available for assessment of liver fibrosis. We aimed to develop a prediction model for liver fibrosis using clinical variables, including LSM.
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Article
No Need of Immediate Treatment for Hypovascular Tumors Associated with Hepatocellular Carcinoma
Hypovascular tumors associated with hepatocellular carcinoma (HCC) can be diagnosed, but it remains unknown whether such lesions should be treated immediately. This study aimed to clarify the clinical signific...
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Article
Open AccessClinical score to predict the risk of bile leakage after liver resection
In liver resection, bile leakage remains the most common cause of operative morbidity. In order to predict the risk of this complication on the basis of various factors, we developed a clinical score system to...
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Article
Surgical Outcomes in Patients with Hepatocellular Carcinoma Associated with Metabolic Syndrome
Only a few papers have focused on the surgical outcomes of patients with hepatocellular carcinoma (HCC) associated with the metabolic syndrome. We compared the outcomes of patients with metabolic HCC with thos...
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Article
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Tatsuhiro Shibata, David Wheeler, Hiroyuki Aburatani and colleagues report the genomic, exomic and oncoviral sequencing of hundreds of liver cancers from the United States and Japan. The authors analyzed mutat...
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Article
Open AccessPRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in S...
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Article
Open AccessA simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network
In the functional genomics analysis domain, various methodologies are available for interpreting the results produced by high-throughput biological experiments. These methods commonly use a list of genes as an...
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Article
Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn’s disease: a multicenter experience
Double-balloon endoscopy (DBE) examinations are not yet widely accepted as routine procedures for examining the small bowel of patients with Crohn’s disease (CD).
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Article
Restoration of gut motility in Kit-deficient mice by bone marrow transplantation
Interstitial cells of Cajal (ICC) play important roles in autonomic gut motility as electrical pacemakers and mediators of neural regulation of smooth muscle functions. Insufficiency of ICC has been reported i...
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Article
Helicobacter Pylori Infection Induces Candidate Stem Cell Marker Musashi-1 in the Human Gastric Epithelium
Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We ...
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Article
Cultured bone marrow cell local implantation accelerates healing of ulcers in mice
The therapeutic potential of bone marrow (BM)-derived cells in ulcers is not known. This study aimed to clarify (1) cell types that are derived from the BM which infiltrate ulcers; (2) whether BM-derived cells...
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Article
Geranylgeranylacetone Induces Cyclooxygenase-2 Expression in Cultured Rat Gastric Epithelial Cells Through NF-κB
Geranylgeranylacetone (GGA) effectively protects the gastric mucosa against noxious agents. The precise mechanisms underlying the gastroprotective actions of GGA are not known. To elucidate the precise mechani...
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Article
Gastroprotective Agent Rebamipide Induces Cyclooxygenase-2 (COX-2) in Gastric Epithelial Cells
Cyclooxyngease-2 (COX-2) is a key enzyme in prostaglandin (PG) synthesis, and COX-2 induction plays an important role in the healing of gastric ulceration. Rebamipide is a gastroprotective agent and attenuates...
