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  1. Article

    Open Access

    Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells

    After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells. However, the regulation from the effector phase to the memory phase has not been eluci...

    Tomonori Iyoda, Kanako Shimizu, Takaho Endo, Takashi Watanabe in Communications Biology (2023)

  2. Article

    Open Access

    Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

    SARS-CoV-2-specific CD8+ T cells are scarce but detectable in unexposed healthy donors (UHDs). It remains unclear whether pre-existing human coronavirus (HCoV)-specific CD8+ T cells are converted to functionally ...

    Kanako Shimizu, Tomonori Iyoda, An Sanpei, Hiroshi Nakazato in Communications Biology (2021)

  3. Article

    Open Access

    Eomes transcription factor is required for the development and differentiation of invariant NKT cells

    Eomes regulates the differentiation of CD8+ T cells into effector and memory phases. However, its role in invariant (i)NKT cells remains unknown. Here, we show the impact of Eomes on iNKT cells in the thymus and ...

    Kanako Shimizu, Yusuke Sato, Masami Kawamura, Hiroshi Nakazato in Communications Biology (2019)