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Article
Metastatic pancreatic cancer with multiple metastases confined to the large intestine: a case report and literature review
The incidence and mortality rate of pancreatic cancer are increasing worldwide. Regional lymph nodes, liver, lung, and peritoneum are common sites of metastasis from pancreatic cancer, but the gastrointestinal...
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Article
Intramucosal signet-ring cell carcinoma with reduced expression of E-cadherin in a Helicobacter pylori-uninfected stomach remained unchanged for 8 years
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Article
Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations
In Helicobacter pylori (Hp)-uninfected individuals, diffuse-type gastric cancer (DGC) was reported as the most common type of cancer. However, the carcinogenic mechanism of Hp-uninfected sporadic DGC is largely u...
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Article
Immunoglobulin A vasculitis without purpura in an elderly female patient: a case report
Immunoglobulin A (IgA) vasculitis mainly affects the joints, skin, kidneys, and gastrointestinal tract; however, purpura is an essential diagnostic criterion. Here, we report an unusual case of IgA vasculitis ...
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Article
Application of a sodium alginate hydrogel for clear preoperative endoscopic marking using India ink
Preoperative marking or tattooing is a clinical procedure conducted during laparoscopic surgeries in which gastrointestinal lesions are identified by injecting India ink. However, diffusion of the carbon parti...
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Article
Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer
Germline mutations in CDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 2...
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Chapter
New Perspectives in Gastric Cancer: Helicobacter pylori-Uninfected Pure Signet Ring Cell Carcinoma
Although gastric cancer incidence and mortality rates remain high in Japan, they have decreased in recent years. This decline is thought to be attributable to the reduction of Helicobacter pylori (HP) infection r...
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Article
Age-related remodelling of oesophageal epithelia by mutated cancer drivers
Clonal expansion in aged normal tissues has been implicated in the development of cancer. However, the chronology and risk dependence of the expansion are poorly understood. Here we intensively sequence 682 mi...
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Article
Open AccessLong-term outcome of definitive radiotherapy for cervical esophageal squamous cell carcinoma
The aim of this study was to identify the long-term clinical outcome of definitive radiotherapy using three-dimensional conformal radiotherapy (3DCRT) for cervical esophageal squamous cell carcinoma (CESCC).
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Article
Open AccessDistinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells
Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. Thi...
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Article
Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia
High-dose 5-fluorouracil (5-FU) containing chemotherapy occasionally causes hyperammonemia and can be lethal. However, the mechanism of 5FU-associated hyperammonemia has not been known. The aim of this study w...
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Article
Open AccessNovel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma
Epidermal growth factor receptor (EGFR) is a key molecule in the pathophysiology of oesophageal squamous cell carcinoma (OSCC). However, EGFR-targeted agents such as anti-EGFR antibody or tyrosine kinase inhib...
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Article
Endoscopic laryngo-pharyngeal surgery for superficial laryngo-pharyngeal cancer
Narrow band imaging (NBI) combined with magnifying endoscopy enables us to detect superficial laryngo-pharyngeal cancers, which are difficult to detect by standard endoscopy. Endoscopic laryngo-pharyngeal surg...
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Article
Open AccessProtective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium
Acetaldehyde is an ethanol-derived definite carcinogen that causes oesophageal squamous cell carcinoma (ESCC). Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that eliminates acetaldehyde and impairment of AL...
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Article
Elimination of esophageal multiple precancerous lesions by chemotherapy: potential chemoprevention of metachronous multiple cancer development after curative treatment
Dysplastic squamous epithelium is a precancerous lesion for squamous cell carcinoma. It is often present in the esophagus and head and neck region, and can be visualized as a Lugol-voiding lesion (LVL) by iodi...
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Article
Cancer risk and management in a woman with Peutz-Jeghers syndrome
Peutz-Jeghers syndrome (PJS) is known to cause an elevated risk of cancer development. We present the case of a 41-year-old Japanese woman with PJS who had various lesions in the abdominal and pelvic organs. T...
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Article
Differences of image enhancement in image-enhanced endoscopy: narrow band imaging versus flexible spectral imaging color enhancement
Narrow band imaging (NBI) can emphasize images of the surface microvasculature of lesions, because the central wavelengths of the NBI filter are 415 and 540 nm and these wavelengths are well absorbed by hemogl...
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Article
Pharmacokinetics of oxaliplatin in a hemodialytic patient treated with modified FOLFOX-6 plus bevacizumab therapy
To establish an appropriate administration schedule for oxaliplatin in FOLFOX plus bevacizumab therapy for a hemodialytic patient.
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Article
Acute Epstein–Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations
Primary Epstein–Barr virus (EBV) infection is usually a self-limiting disease. Although it is sometimes accompanied by severe complications such as thrombocytopenia, hemolytic anemia, and splenic rupture, pred...
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Article
Multiple early-stage malignant melanoma of the esophagus with long follow-up period after endoscopic treatment: report of a case
Primary malignant melanoma of the esophagus (PMME) is a rare disease. Most patients are diagnosed at an advanced stage and few at an early stage. We report a patient with multiple early-stage PMME (tumor invas...
