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  1. No Access

    Article

    Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan

    Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.

    Chin-Wei Chang, Wei-Fan Hsu, Kuo-Chih Tseng, Chi-Yi Chen in Digestive Diseases and Sciences (2024)

  2. No Access

    Article

    The effect of calcium oxalate stones and uric acid stones on male sexual function

    This study compared the effects of calcium oxalate stones and uric acid stones on male sexual function.

    Jian Chen, Nannan Pang, Jianlin Lu, Guodao Liu in International Urology and Nephrology (2024)

  3. Article

    Open Access

    Heat-related illness and dementia: a study integrating epidemiological and experimental evidence

    Heat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We conducted a population-based cohort study and an animal experiment to ...

    Wan-Yin Kuo, Chien-Cheng Huang, Chi-An Chen, Chung-Han Ho in Alzheimer's Research & Therapy (2024)

  4. No Access

    Article

    Impact of hepatic artery variation on surgical and oncological outcomes in robotic pancreaticoduodenectomy

    In patients with hepatic artery variation (HAV), feasibility and justification of robotic pancreatoduodenectomy (RPD) for periampullary lesions have been not been well established.

    Hsuan-Hsuan Yu, Shin-E Wang, Bor-Shiuan Shyr, Shih-Chin Chen in Surgical Endoscopy (2024)

  5. Article

    Open Access

    Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy

    To unveil the candidate susceptibility genes in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy using whole exome sequencing (WES) and genome-wide association study (GWAS).

    Hsun-I Chiu, Hui-Chen Cheng, Chih-Chiau Wu, Shih-Jen Chen, De-Kuang Hwang in Eye (2024)

  6. Article

    Open Access

    A Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19

    Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.

    Wang-Da Liu, Po-Hao Feng, Chien-Yu Cheng in Infectious Diseases and Therapy (2024)

  7. Article

    Open Access

    Likelihood-of-harm/help of microsurgery compared to radiosurgery in large vestibular schwannoma

    It has been shown that in large vestibular schwannomas (VS), radiosurgery (SRS) is inferior with respect to tumor control compared to microsurgical resection (SURGERY). However, SURGERY poses a significantly high...

    Sophie Shih-Yüng Wang, Gerhard Horstmann, Albertus van Eck in Journal of Neuro-Oncology (2024)

  8. Article

    Open Access

    Sub-seasonal prediction skill: is the mean state a good model evaluation metric?

    Evaluating forecast models encompasses assessing their ability to accurately depict observed climate states and predict future climate variables. Various evaluation methods, from computationally efficient meas...

    Jihun Ryu, Shih-Yu (Simon) Wang, Jee-Hoon Jeong, **-Ho Yoon in Climate Dynamics (2024)

  9. Article

    Open Access

    A time of emergence (TOE) analysis on the impact and uncertainty of global warming on Korean peak summers

    In recent years, South Korea has experienced a notable escalation in the intensity and frequency of summer heat. To quantitatively gauge the impact of global warming on Korean summers, this study employs the T...

    Jihun Ryu, Shih-Yu (Simon) Wang, **-Ho Yoon in Climatic Change (2024)

  10. Article

    Open Access

    Cystic vestibular schwannoma – a subgroup analysis from a comparative study between radiosurgery and microsurgery

    Some vestibular schwannoma (VS) show cystic morphology. It is known that these cystic VS bear different risk profiles compared to solid VS in surgical treatment. Still, there has not been a direct comparative ...

    Sophie Shih-Yüng Wang, Ahmed Rizk, Florian H. Ebner in Neurosurgical Review (2024)

  11. No Access

    Article

    Health-related quality of life by veterans RAND 12 and healthcare resource utilization in cancer patients with sleep disorders: insights from the Medical Expenditure Panel Survey

    This study aims to investigate the joint effects of cancer and sleep disorders on the health-related quality of life (HRQoL), healthcare resource utilization, and expenditures among US adults.

    Yuan Kao, Ying-Jia Lin, Shih-Feng Weng, Jhi-Joung Wang in Supportive Care in Cancer (2024)

  12. Article

    Open Access

    Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å

    While cryogenic electron microscopy (cryo-EM) is fruitfully used for harvesting high-resolution structures of sizable macromolecules, its application to small or flexible proteins composed of small domains lik...

    Hsin-Hung Lin, Chun-Hsiung Wang, Shih-Hsin Huang, Sung-Yao Lin in Scientific Reports (2024)

  13. Article

    Open Access

    Intrinsically stretchable organic photovoltaics by redistributing strain to PEDOT:PSS with enhanced stretchability and interfacial adhesion

    Intrinsically stretchable organic photovoltaics have emerged as a prominent candidate for the next-generation wearable power generators regarding their structural design flexibility, omnidirectional stretchabi...

    Jiachen Wang, Yuto Ochiai, Niannian Wu, Kiyohiro Adachi in Nature Communications (2024)

  14. Article

    Open Access

    Power-Doppler-based NH002 microbubble sonoporation with chemotherapy relieves hypoxia and enhances the efficacy of chemotherapy and immunotherapy for pancreatic tumors

    Pancreatic ductal adenocarcinoma (PDAC) poses challenges due to late-stage diagnosis and limited treatment response, often attributed to the hypoxic tumor microenvironment (TME). Sonoporation, combining ultras...

    Sheng-Yan Wu, Chung-Hsin Wang, Shih-Tsung Kang, Ching-Fang Yu in Scientific Reports (2024)

  15. No Access

    Article

    Healthcare Utilization and Its Correlates in Comorbid Type 2 Diabetes Mellitus and Generalized Anxiety Disorder

    This study investigated the healthcare utilization and medical expenditure of type 2 diabetes mellitus (T2DM) patients with generalized anxiety disorder (GAD) and identified the associated factors. The healthc...

    Chun-Jen Huang, Ching-Hua Lin, Tai-Ling Liu, Pai-Cheng Lin in Psychiatric Quarterly (2024)

  16. Article

    Open Access

    Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury

    Maleic acid (MA) induces renal tubular cell dysfunction directed to acute kidney injury (AKI). AKI is an increasing global health burden due to its association with mortality and morbidity. However, targeted t...

    Hugo Y.-H. Lin, Chan-Jung Liang, Ming-Yu Yang, Phang-Lang Chen, Tzu-Ming Wang in Apoptosis (2024)

  17. Article

    Open Access

    Examining arterial pulsation to identify and risk-stratify heart failure subjects with deep neural network

    Hemodynamic parameters derived from pulse wave analysis have been shown to predict long-term outcomes in patients with heart failure (HF). Here we aimed to develop a deep-learning based algorithm that incorpor...

    Chieh-Chun Huang, Shih-Hsien Sung in Physical and Engineering Sciences in Medic… (2024)

  18. No Access

    Article

    Effects of Long-term Climate Change on Typhoon Rainfall Associated with Southwesterly Monsoon Flow near Taiwan: Mindulle (2004) and Morakot (2009)

    Chung-Chieh Wang, Li-Shan Tseng in Asia-Pacific Journal of Atmospheric Scienc… (2024)

  19. No Access

    Article

    On the Phase Configurational Entropy of Dual-Phase γ/γ′ Multi-principal Element Alloys: A Case Study on the Al–Cu–Fe–Ni–Ti System

    Configurational entropy is an important indicator of the formability of single solid solutions in multi-principal element alloys, typically estimated by using nominal compositions. However, nearly half of repo...

    Shao-yu Yen, Hao-che Wang, Shih-kang Lin in High Entropy Alloys & Materials (2024)

  20. Article

    Open Access

    Urban people’s preferences for life-sustaining treatment or artificial nutrition and hydration in advance decisions

    The Patient Right to Autonomy Act (PRAA), implemented in Taiwan in 2019, enables the creation of advance decisions (AD) through advance care planning (ACP). This legal framework allows for the withholding and ...

    Yi-Ling Wu, Tsai-Wen Lin, Chun-Yi Yang, Samuel Shih-Chih Wang in BMC Medical Ethics (2024)

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