54 Result(s)

Article

Blood pressure lowering effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA)

Shigeru Toyoda in Hypertension Research (2024)

Article

Transcatheter aortic valve-in-surgical aortic valve for a patient with repeated healed endocarditis: a case report

Transcatheter valve replacement is contraindicated in patients with active infective endocarditis. However, few reports suggest that it could be beneficial for high-risk surgical patients with healed infective...

Yusuke Takei, Ryujiro Suzuki, Ikuko Shibasaki, Michiaki Tokura… in Surgical Case Reports (2023)

Article

Efficacy of azilsartan on left ventricular diastolic dysfunction compared with candesartan: J-TASTE randomized controlled trial

Characterized by ventricular and vascular stiffness, heart failure with preserved ejection fraction (HFpEF) has led to high morbidity and mortality. As azilsartan is an angiotensin receptor blocker with the hi...

Shin Ito, Hiroyuki Takahama, Masanori Asakura, Yukio Abe… in Scientific Reports (2023)

Article

Rationale and design of an investigator-initiated, multicenter, prospective, placebo-controlled, double-blind, randomized trial to evaluate the effects of finerenone on vascular stiffness and cardiorenal biomarkers in type 2 diabetes and chronic kidney disease (FIVE-STAR)

The overactivation of mineralocorticoid receptor (MR) plays a key pathological role in the progression of cardiovascular and renal diseases by promoting pro-inflammatory and pro-fibrotic signaling. Recently, i...

Atsushi Tanaka, Hirotaka Shibata, Takumi Imai, Hisako Yoshida… in Cardiovascular Diabetology (2023)

Article

Long-term observation of estimated fluid volume reduction after the initiation of ipragliflozin in patients with type 2 diabetes mellitus: a sub-analysis from a randomized controlled trial (PROTECT)

Recent studies have shown that the addition of sodium-glucose co-transporter 2 (SGLT2) inhibitors gradually reduces the estimated fluid volume parameters in a broad range of patient populations, suggesting tha...

Atsushi Tanaka, Takumi Imai, Shigeru Toyoda… in Diabetology & Metabolic Syndrome (2023)

Article

Intraprocedural assessment of commissural alignment of the Navitor system using the en-face view

Suguru Hirose, Masaki Nakashima, Yusuke Enta… in Cardiovascular Intervention and Therapeuti… (2023)

Article

Effects of the factor Xa inhibitor rivaroxaban on the differentiation of endothelial progenitor cells

We evaluated the efficacy of the factor Xa inhibitor rivaroxaban on the differentiation ability of vascular endothelial progenitor cells (EPCs), which play roles in vascular injury repair and atherogenesis. An...

Ryoichi Sohma, Masashi Sakuma, Syotaro Obi, Setsu Nishino… in BMC Cardiovascular Disorders (2023)

Article

Could the control of O-GlcNAcylation play a key role in cardiac remodeling?

Shigeru Toyoda, Naoyuki Otani in Hypertension Research (2023)

Article

Optimal target of LDL cholesterol level for statin treatment: challenges to monotonic relationship with cardiovascular events

Aggressive lipid lowering by high-dose statin treatment has been established for the secondary prevention of coronary artery disease (CAD). Regarding the low-density lipoprotein cholesterol (LDL-C) level, howe...

Masashi Sakuma, Satoshi Iimuro, Tomohiro Shinozaki, Takeshi Kimura… in BMC Medicine (2022)

Article

Association between serum insulin levels and heart failure-related parameters in patients with type 2 diabetes and heart failure treated with canagliflozin: a post-hoc analysis of the randomized CANDLE trial

Insulin resistance and hyperinsulinemia in patients with type 2 diabetes (T2D) are adversely associated with the development and worsening of heart failure (HF). Herein, we sought to investigate the effect of ...

Atsushi Tanaka, Takumi Imai, Michio Shimabukuro, Isao Taguchi… in Cardiovascular Diabetology (2022)

Article

Effect of canagliflozin on N-terminal pro-brain natriuretic peptide in patients with type 2 diabetes and chronic heart failure according to baseline use of glucose-lowering agents

Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of a deterioration in heart failure (HF) and mortality in patients with a broad range of cardiovascular risks. Recent guidelines recommend cons...

Atsushi Tanaka, Shigeru Toyoda, Takumi Imai, Kazuki Shiina… in Cardiovascular Diabetology (2021)

Article

Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome

This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary ...

Masashi Sakuma, Setsu Nishino, Takahisa Nasuno, Michiya Kageyama… in Scientific Reports (2021)

Article

Comparison of the clinical effect of empagliflozin on glycemic and non-glycemic parameters in Japanese patients with type 2 diabetes and cardiovascular disease treated with or without baseline metformin

The most recent treatment guidelines for type 2 diabetes (T2D) recommend sodium-glucose cotransporter 2 (SGLT2) inhibitors should be considered preferentially in patients with T2D with either a high cardiovasc...

Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa… in Cardiovascular Diabetology (2021)

Article

Reduction of estimated fluid volumes following initiation of empagliflozin in patients with type 2 diabetes and cardiovascular disease: a secondary analysis of the placebo-controlled, randomized EMBLEM trial

Sodium glucose co-transporter 2 inhibitors promote osmotic/natriuretic diuresis and reduce excess fluid volume, and this improves cardiovascular outcomes, including hospitalization for heart failure. We sought...

Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa… in Cardiovascular Diabetology (2021)

Article

Usefulness of dual-axis rotational coronary angiography in primary percutaneous coronary intervention for patients with ST-elevation myocardial infarction

Several studies have shown that dual-axis rotational coronary angiography (DARCA) reduces contrast medium volume and radiation exposure compared to conventional coronary angiography (CCA). However, there are n...

Hideaki Suwa, Yota Koyabu, Taichi Adachi, Akira Kawai, Kazuhiko Kotani… in Heart and Vessels (2021)