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Article
Open AccessDeep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus
Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the sco...
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Article
Open AccessSMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacit...
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Article
Open AccessParticle flow simulation of Brazilian splitting failure characteristics of layered shale
Shale reservoir is the research hotspot in the development of unconventional oil and gas resources. The properties of bedding plane have an important influence on the mechanical behavior of shale. According to...
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Article
Retraction Note: Numerical simulation and analysis of the three-step excavation of an extra-large cross section and a low flat-ratio railway tunnel
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Open AccessHOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring
The body plan of animals is laid out by an evolutionary-conserved HOX code which is colinearly transcribed after zygotic genome activation (ZGA). Here we report that SMCHD1, a chromatin-modifying enzyme needed...
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Article
Open AccessFinite Element Method on Shape Memory Alloy Structure and Its Applications
It is significant to numerically investigate thermo-mechanical behaviors of shape memory alloy (SMA) structures undergoing large and uneven deformation for they are used in many engineering fields to meet spec...
