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Article
The formation mechanism of discontinuously segmented chip in high-speed cutting of Ti-6Al-4 V
The chip transition from continuously serrated to discontinuously segmented is one of the most fundamental and challenging problems in metal cutting. In this work, a reliable finite element model for high spee...
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Article
Dimension-dependent mechanical features of Au-nanocrystalline nanofilms
For metal nanofilms composed of nanocrystals, the multiple deformation mechanisms will coexist and bring unique and complex elastic-plastic and fracture mechanical properties. By successfully fabricating large...
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Article
Open AccessDeep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus
Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the sco...
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Article
Open AccessSMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacit...
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Article
Open AccessParticle flow simulation of Brazilian splitting failure characteristics of layered shale
Shale reservoir is the research hotspot in the development of unconventional oil and gas resources. The properties of bedding plane have an important influence on the mechanical behavior of shale. According to...
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Article
Retraction Note: Numerical simulation and analysis of the three-step excavation of an extra-large cross section and a low flat-ratio railway tunnel
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Article
Direct identification of A-to-I editing sites with nanopore native RNA sequencing
Inosine is a prevalent RNA modification in animals and is formed when an adenosine is deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly as variants from Illumina RNA-s...
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Article
Open AccessHOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring
The body plan of animals is laid out by an evolutionary-conserved HOX code which is colinearly transcribed after zygotic genome activation (ZGA). Here we report that SMCHD1, a chromatin-modifying enzyme needed...
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Chapter and Conference Paper
Study on Optimization Method of Structural Parameters About Jetting and Helical Combination Drain Tool
In order to carry out drainage gas recovery at low cost, a jet cyclone compound drainage tool was designed and its structural parameters were optimized. According to the movement characteristics of the mixed f...
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Article
RETRACTED ARTICLE: Numerical simulation and analysis of the three-step excavation of an extra-large cross section and a low flat-ratio railway tunnel
The **nbaishiyan tunnel in the reconstruction Chengdu–Kunming railway Ermeishan-Mipan section mainly runs through dolomite with dolomitic limestone, with an excavation area of 260 m2, a maximum span of 22.3 m, a ...
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Chapter and Conference Paper
The Application of Time–Domain DQM to the Dynamically Forced Vibration of Simply Supported Plates
The time–domain DQM is for discretizing space domain of continuous functions as well as time domain of that. In this paper, a study of the forced vibration of simply supported plates subjected to a transverse ...
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Article
Numerical Simulation on Coiled Tubing Erosion During Hydraulic Fracturing
Hydraulic fracturing operation through coiled tubing is a safe, economical, and efficient well stimulation technique. During the operation, the wall of coiled tubing spooled on the reel is abraded and eroded b...
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Article
Fatigue Lifetime Prediction for Oil Tube Material Based on ABAQUS and FE-SAFE
A novel approach for the fatigue life prediction based on the combination of FE simulation using ABAQUS and fatigue analysis in FE-SAFE has been proposed in this paper. A phenomenological constitutive equation...
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Article
Modeling size-dependent thermo-mechanical behaviors of shape memory polymer Bernoulli-Euler microbeam
The objective of this paper is to model the size-dependent thermo-mechanical behaviors of a shape memory polymer (SMP) microbeam. Size-dependent constitutive equations, which can capture the size effect of the...
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Article
Open AccessFinite Element Method on Shape Memory Alloy Structure and Its Applications
It is significant to numerically investigate thermo-mechanical behaviors of shape memory alloy (SMA) structures undergoing large and uneven deformation for they are used in many engineering fields to meet spec...
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Article
Quantification of strain-induced damage in semi-crystalline polymers: a review
Semi-crystalline polymers are now extensively used in various applications such as aircrafts, civilian structures, oil and gas platforms and electronics. They are, however, inherently damage prone, and over ti...
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Article
De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development
Jeanne Amiel, Bernd Wollnik, Bruno Reversade and colleagues report de novo missense mutations in SMCHD1 in patients with Bosma arhinia microphthalmia syndrome (BAMS) and isolated arhinia. Mechanistic studies supp...
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Article
RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation
Emerging evidence suggests that the ribosome has a regulatory function in directing how the genome is translated in time and space. However, how this regulation is encoded in the messenger RNA sequence remains...
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Article
Specialized ribosomes: a new frontier in gene regulation and organismal biology
Historically, the ribosome has been viewed as a constitutive molecular machine with little regulatory capacity in mRNA translation. However, recent findings su...
