Skip to main content

1 Result(s)

within Shi-You Jiang Remove this filter

and

  1. Article

    Open Access

    Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

    Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat cardiovascular disease. However, a paradoxical increase of reductase pr...

    Shi-You Jiang, Hui Li, **g-Jie Tang, Jie Wang, Jie Luo, Bing Liu… in Nature Communications (2018)

    Download PDF (1967 KB) View Article