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Article
Open AccessEpigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent need for develo** novel treatment options. Identifying epigenetic vulnerabilities of c...
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Article
TAS2R38 bitter taste perception in the Koṅkaṇī Sārasvata Brahmin population
The TAS2R38 gene carries markers for phenylthiocarbamide (PTC) sensitivity. Various studies have investigated the genotype–phenotype association pattern for bitter tasting ability and other factors in different p...
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Article
Open AccessMulti-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other typ...
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Article
Open AccessDissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup
The global distribution of J2-M172 sub-haplogroups has been associated with Neolithic demic diffusion. Two branches of J2-M172, J2a-M410 and J2b-M102 make a considerable part of Y chromosome gene pool of the I...
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Article
Open AccessGenome-wide analysis correlates Ayurveda Prakriti
The practice of Ayurveda, the traditional medicine of India, is based on the concept of three major constitutional types (Vata, Pitta and Kapha) defined as “Prakriti”. To the best of our knowledge, no study has c...
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Article
Open Accessc.620C>T mutation in GATA4 is associated with congenital heart disease in South India
Congenital heart diseases (CHDs) usually refer to abnormalities in the structure and/or function of the heart that arise before birth. GATA4 plays an important role in embryonic heart development, hence the aim o...
