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Recent progress in PTH/PTHrP research
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Parathyroid Hormone and the Myocardiopathy of Chronic Renal Failure
Patients with advanced chronic renal failure (CRF) and those treated with dialysis display a large number of cardiovascular complications. These are listed in table 9–1. These patients may suffer from myocardi...
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Book
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Book
Tubulo-Interstitial Nephropathies
Proceedings of the 4th Bari Seminar in Nephrology, Bari, Italy, April 25–28, 1990
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Renal Osteodystrophy
Patients with end-stage renal failue display a multitude of signs and symptoms produced by derangements in the metabolism of divalent ions, vitamin D, parathyroid hormone, and bone (1). These abnormalities are...
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Book
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Book
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Polymorphonuclear Leucocytes are a Target for Parathyroid Hormone: An Effect on their Random Migration
Defective leukocyte function manifested by impaired migration (1, 2) and reduced phagocytic (3–5) and bactericidal activity (6) has been observed in patients with uraemia. Also, sera from dialysis patients con...
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The Effect of Parathyroid Hormone on Cisplatin Nephrotoxicity
The clinical use of cisplatin as an antineoplastic agent is limited by its nephrotoxicity that, in many cases, includes acute tubular necrosis and renal wasting of various electrolytes (1–4). Several studies h...
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Carbohydrate Intolerance and Impaired Pancreatic Insulin Release in Chronic Renal Failure: Role of Excess Blood Levels of Parathyroid Hormone
Patients with chronic renal failure display abnormalities in carbohydrate metabolism (1–5). They almost always have resistance to the peripheral action of insulin (5, 6), while insulin secretion could be norma...
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Derangements in Brain Synaptosomes Function in Chronic Renal Failure: Role of Parathyroid Hormone
The neurotoxicity of excess blood levels of PTH in uremic state is well documented (1–4). This deleterious effect of the hormone is, at least in part, due to its ability to increase calcium content in brain (5...
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Book
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Book
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Chapter
Parathyroid Hormone: A Uremic Toxin
A Sundry of clinical, biochemical and radiographic abnormalities occur in patients with advanced renal failure. These are listed in Table 1, and they constitute the uremic syndrome. Their pathogenesis have bee...
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Book
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Book
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Rhabdomyolysis: A Clinical Entity for the Study of Role of Proteases
Many of the readers of these proceedings may be surprised to find the clinical subject of rhabdomyolysis included in a symposium dealing with the biochemistry and biology of proteases. However, a deeper look i...
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The Relationship between Body Phosphate and Blood Pressure
Phosphate depletion alters the function of the cardiovascular system. Decreased myocardial performance has been described in phosphate depleted dogs (1) and humans (2). In the most severe cases of hypophosphat...
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Chapter
The Myopathy of Phosphate Depletion
Phosphate depletion is commonly associated with proximal muscle weakness, muscle pain, impaired resting membrane potential (1) and mild elevation of creatine phosphokinase and aldolase (1). Phosphorus depletio...
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Chapter
Hypomagnesemia and Hypermagnesemia
The body of the adult human contains about 2000 mEq of magnesium with half of it in the skeleton and the other half in soft tissues (1). The concentration of magnesium is highest (15 to 20 mEq/kg wet weight) i...
