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Article
Open AccessThe cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region
Recent genome-wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the Chr9p21 region are associated with coronary artery disease (CAD). Most of the SNPs identified in this...
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Article
Open AccessAssociations between self-referral and health behavior responses to genetic risk information
Studies examining whether genetic risk information about common, complex diseases can motivate individuals to improve health behaviors and advance planning have shown mixed results. Examining the influence of ...
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Article
Open AccessGenetic diversity is a predictor of mortality in humans
It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both...
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Article
Open AccessIdentified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population
Diabetic nephropathy (DN) has become one of the most common causes of end-stage renal disease (ESRD) in many countries, such as 44.5% in Taiwan. Previous studies have shown that there is a genetic component to...
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Article
Open AccessThe relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3
Single nucleotide polymorphisms (SNPs) within the 9p21.3 genomic region have been consistently associated with coronary heart disease (CHD), myocardial infarction, and quantity of coronary artery calcification...
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Article
Open AccessJoint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: The Taichung Diabetes Study
Estimated glomerular filtration rate (eGFR) is a powerful predictor of mortality in diabetic patients with limited proteinuria data. In this study, we tested whether concomitant proteinuria increases the risk ...
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Article
Open AccessIdentification of genes associated with complex traits by testing the genetic dissimilarity between individuals
Using the exome sequencing data from 697 unrelated individuals and their simulated disease phenotypes from Genetic Analysis Workshop 17, we develop and apply a gene-based method to identify the relationship be...
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Article
Open AccessMetabolic syndrome is associated with change in subclinical arterial stiffness - A community-based Taichung Community Health Study
The aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study.
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Article
Open AccessSoftware comparison for evaluating genomic copy number variation for Affymetrix 6.0 SNP array platform
Copy number data are routinely being extracted from genome-wide association study chips using a variety of software. We empirically evaluated and compared four freely-available software packages designed for A...
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Article
Open AccessSNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in african-americans of the GENOA study
Left ventricular mass (LVM) is a strong, independent predictor of heart disease incidence and mortality. LVM is a complex, quantitative trait with genetic and environmental risk factors. This research characte...
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Article
Open AccessThe relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population
High-sensitivity C-reactive protein (hs-CRP) is an easily measured inflammatory biomarker. This study compared the association of percent body fat mass (%FM), body mass index (BMI), waist circumference (WC), a...
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Article
Open AccessSex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population
Although sex differences have been reported for associations between components of metabolic syndrome and inflammation, the question of whether there is an effect modification by sex in the association between...
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Article
Open AccessIdentification of correlated genetic variants jointly associated with rheumatoid arthritis using ridge regression
Using the North American Rheumatoid Arthritis Consortium genome-wide association dataset, we applied ridged, multiple least-squares regression to identify genetic variants with apparent unique contributions to...
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Article
Open AccessComplexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study
Subcortical white matter hyperintensity on magnetic resonance imaging (MRI) of the brain, referred to as leukoaraiosis, is associated with increased risk of stroke and dementia. Hypertension may contribute to ...
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Article
Open AccessMultiple interactions between the alpha2C- and beta1-adrenergic receptors influence heart failure survival
Persistent stimulation of cardiac β1-adrenergic receptors by endogenous norepinephrine promotes heart failure progression. Polymorphisms of this gene are known to alter receptor function or expression, as are pol...
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Article
Open AccessInvestigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites
Atherosclerotic peripheral arterial disease (PAD) affects 8–10 million people in the United States and is associated with a marked impairment in quality of life and an increased risk of cardiovascular events. ...
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Article
Open AccessClassification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests
Using the North American Rheumatoid Arthritis Consortium (NARAC) candidate gene and genome-wide single-nucleotide polymorphism (SNP) data sets, we applied regression methods and tree-based random forests to id...
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Article
Open AccessInteractions between the adducin 2gene and antihypertensive drug therapies in determining blood pressure in people with hypertension
As part of the NHLBI Family Blood Pressure Program, the Genetic Epidemiology Network of Arteriopathy (GENOA) recruited 575 sibships (n = 1583 individuals) from Rochester, MN who had at least two hypertensive s...
