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Article
Improved Long-term Survival with Remote Limb Ischemic Preconditioning in a Rat Fixed-Pressure Hemorrhagic Shock Model
We investigated whether bilateral, lower limb remote ischemic preconditioning (RIPC) improved long-term survival using a rat model of hemorrhagic shock/resuscitation.
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Article
New and revisited approaches to preserving the reperfused myocardium
Mortality after acute ST-segment elevation myocardial infarction (STEMI) has plateaued in the past decade, after a period of continual decline
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Article
Cardioprotection: Where to from here?
The size of the myocardial infarction remains an important therapeutic target, because heart attack size correlates with mortality and heart failure. In this era, myocardial infarct size is reduced primarily b...
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Article
Open AccessDoes sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias?
Whether sex affects the acute phase of myocardial ischemia in experimental animal models is currently being debated. Our purpose was to determine if sex influences either the incidence or severity of reperfusi...
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Article
Dabigatran treatment: effects on infarct size and the no-reflow phenomenon in a model of acute myocardial ischemia/reperfusion
The no-reflow phenomenon occurs when an epicardial coronary artery is reopened following myocardial infarction, but portions of the intramural microvasculature fail to reperfuse. One potential mechanism for th...
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Article
Ranolazine Treatment for Myocardial Infarction? Effects on the Development of Necrosis, Left Ventricular Function and Arrhythmias in Experimental Models
Ranolazine, an inhibitor of the late current of the cardiac action potential (late INa), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role ...
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Article
Capsaicin-Induced Cardioprotection. Is Hypothermia or the Salvage Kinase Pathway Involved?
Topical capsaicin application was shown to reduce infarct size in experimental animal models. We hypothesized that cardioprotective properties of topical capsaicin application could be related to its hypotherm...
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Article
Acetaminophen and Experimental Acute Myocardial Infarction
Acetaminophen is a widely used analgesic, and recent studies have shown that it has some benefits in the ischemic heart. The purpose of this study was to test the effects of acetaminophen on infarct size, regi...
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Article
What is the Required Reperfusion Period for Assessment of Myocardial Infarct Size Using Triphenyltetrazolium Chloride Staining in the Rat?
Measurements of infarct size by use of tripenyltetrazoliumchloride (TTC) is a widely accepted method used to delineate the extent of myocardial necrosis following coronary occlusion and reperfusion in various ...
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Article
Acute ethanol does not protect against ischemic/ reperfusion injury in rabbit myocardium
Moderate use of alcohol has shown protective effects in coronary artery disease, while excessive use has been associated with cardiomyopathy and hypertension. Since alcohol is a vasodilator, we postulated that...
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Article
Do antioxidant vitamins reduce infarct size following acute myocardial ischemia/reperfusion?
There is controversy concerning the ability of antioxidant vitamins to reduce myocardial infarct size. We sought to determine whether a brief prophylactic treatment of vitamin C or vitamin C plus Trolox (a wat...
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Chapter
Role of leukocytes in reperfusion injury
Reperfusion represents a paradoxical situation with both beneficial and potentially detrimental consequences to the ischemic myocardium. Reperfusion is essential for the survival of myocytes subjected to sever...
