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    Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides

    The lissoclimides are unusual succinimide-containing labdane diterpenoids that were reported to be potent cytotoxins. Our short semisynthesis and analogue-oriented synthesis approaches provide a series of liss...

    Zef A. Könst, Anne R. Szklarski, Simone Pellegrino, Sharon E. Michalak… in Nature Chemistry (2017)