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Article
Open AccessGenome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-...
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Article
Open AccessCo-existence of leiomyomas, adenomyosis and endometriosis in women with endometrial cancer
Leiomyomas, adenomyosis, and endometriosis are reported to be risk factors for endometrial carcinoma (EC), and adenomyosis and endometriosis also for ovarian carcinoma (OC). We aimed to describe the prevalence...
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Article
Open AccessGenome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candid...
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Article
Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium
Cancer antigen 125 (CA125) is a glycoprotein expressed by epithelial cells of several normal tissue types and overexpressed by several epithelial cancers. Serum CA125 levels are mostly used as an aid in the di...
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Article
Correction: Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer
Nat. Genet. 42, 880–884 (2010); published online 19 September 2010; corrected after print 7 December 2015 In the version of this article initially published, the name of author Angela Brooks-Wilson was spelled...
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Article
Open AccessPaclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer
ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant ...
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Article
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations ...
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Article
No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women
ABCC11 is an ATP-binding cassette transporter responsible for the transport of a diverse range of lipophilic compounds. A single nucleotide polymorphism (SNP) encoding an amino acid change has recently been sh...
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Article
Common variants at 19p13 are associated with susceptibility to ovarian cancer
Paul Pharoah and colleagues report a genome-wide association study for survival time after diagnosis of epithelial ovarian cancer and a parallel analysis of susceptibility to epithelial ovarian cancer. They id...
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Article
No evidence that GATA3 rs570613 SNP modifies breast cancer risk
GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. The ...
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Article
The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case–control and family analysis
BARD1 was first identified as a BRCA1-interacting protein with tumour-suppressor functions. Some association studies suggested that the BARD1 Cys557Ser variant might be associated with increased risk of breast ca...
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Article
Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies
Association studies aimed at identifying breast cancer susceptibility variants in the progesterone receptor (PGR) gene have been previously reported in the literature with conflicting results, ranging from a prot...
