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Article
Open AccessInterferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysi...
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Article
Open AccessOutcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy
The rate of pathological complete response (pCR) for patients with triple negative breast cancer (TNBC) is increased when carboplatin is added to neo-adjuvant chemotherapy (NACT). However, while phase III tria...
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Article
Open AccessReproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study
Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentiall...
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Article
Open AccessMesenchymal stem cells: key players in cancer progression
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...
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Mechanisms of Nitric Oxide-Dependent Regulation of Tumor Invasion and Metastasis
The nitric oxide synthases (NOS) are key enzymes activated as part of the wound healing and host immune response. Their product nitric oxide (NO) is a short-lived, pleiotropic molecule that is a key physiologi...
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Article
Open AccessEts-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer
The Ets-1 transcription factor is a candidate breast cancer oncogene that regulates the expression of genes involved in tumor progression and metastasis. Ets-1 signaling has also been linked to the development...
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Article
Open AccessCOX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer
Inducible cyclooxgenase-2 (COX-2) is commonly overexpressed in breast tumors and is a target for cancer therapy. Here, we studied the association of COX-2 with breast cancer survival and how this association i...
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Chapter
Nitric Oxide and Cancer: An Overview
An involvement of nitric oxide, a diatomic radical, has been described for numerous areas from environmental pollution to cardiovascular disease, carcinogenesis, tumor progression, genotoxicity, and angiogenes...
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Article
Open AccessThe 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells
A number of recent studies have suggested that cancer incidence rates may be lower in patients receiving statin treatment for hypercholesterolemia. We examined the effects of statin drugs on in vitro proliferatio...
