-
Article
Open AccessmiR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson’s disease model via regulation of Nox4/ROS/Nrf2 signaling
The pathogenesis of Parkinson's disease (PD) has not been fully elucidated, and there are no effective disease-modifying drugs for the treatment of PD. Mesenchymal stem cells have been used to treat several di...
-
Article
Open AccessFunctional investigation of SLC1A2 variants associated with epilepsy
Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clear...
-
Article
Open AccessAn anti-inflammatory and anti-fibrotic proprietary Chinese medicine nasal spray designated as Allergic Rhinitis Nose Drops (ARND) with potential to prevent SARS-CoV-2 coronavirus infection by targeting RBD (Delta)- angiotensin converting enzyme 2 (ACE2) binding
Since the outbreak of COVID-19 has resulted in over 313,000,000 confirmed cases of infection and over 5,500,000 deaths, substantial research work has been conducted to discover agents/ vaccines against COVID-1...
-
Article
Open AccessFenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system
The synthetic pyrethroid derivative, fenpropathrin, is a widely used insecticide. However, a variety of toxic effects in mammals have been reported. In particular, fenpropathrin induces degeneration of dopamin...
-
Article
Peripheral Lymphocyte Subsets as a Marker of Parkinson’s Disease in a Chinese Population
In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson’s disease (PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. Th...
-
Article
Open AccessRapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease
Rapamycin protects mice against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss of dopaminergic neurons, which is an established model for Parkinson’s disease. We demonstrated that rapamycin p...
-
Article
Open AccessRegulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model
Glutamate transporters play a key role in glutamate clearance and protect the central nervous system from glutamate excitotoxicity. Dysfunctional glutamate transporters contribute to the pathogenesis of Parkin...
-
Article
Suppression of interleukin 17 contributes to the immunomodulatory effects of adipose-derived stem cells in a murine model of systemic lupus erythematosus
Due to roles in immunoregulation and low immunogenicity, mesenchymal stem cells have been suggested to be potent regulators of the immune response and may represent promising treatments for autoimmune disease....
-
Article
Open AccessTM4 of the glutamate transporter GLT-1 experiences substrate-induced motion during the transport cycle
Excitatory amino acid transporter 2 (EAAT2), also known as glial glutamate transporter type 1 (GLT-1), plays an important role in maintaining the extracellular glutamate concentrations below neurotoxic levels....
-
Article
Open AccessThe biomarkers of immune dysregulation and inflammation response in Parkinson disease
Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histoco...
-
Article
Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-κB/JNK/c-Jun Signaling
Ceftriaxone has been shown to attenuate the dopaminergic neuron death and alleviate behavioral disorders in Parkinson’s disease models via upregulation of glutamate transporter-1 (GLT-1) and decreases in extra...
-
Article
Cysteine mutagenesis reveals alternate proximity between transmembrane domain 2 and hairpin loop 1 of the glutamate transporter EAAT1
Excitatory amino acid transporter 1 (EAAT1) plays an important role in restricting the neurotoxicity of glutamate. Previous structure–function studies have provided evidence that reentrant helical hairpin loop...
-
Chapter and Conference Paper
Making Peer-to-Peer Keyword Searching Feasible Using Multi-level Partitioning
This paper discusses large scale keyword searching on top of peer-to-peer (P2P) networks. The state-of-the-art keyword searching techniques for unstructured and structured P2P systems are query flooding and in...
