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Simultaneous profiling of chromatin architecture and transcription in single cells
The three-dimensional structure of chromatin plays a crucial role in development and disease, both of which are associated with transcriptional changes. However, given the heterogeneity in single-cell chromati...
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Open AccessPCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions
Polycomb group (PcG) ring finger protein 6 (PCGF6), though known as a member of the transcription-repressing complexes, PcG, also has activation function in regulating pluripotency gene expression. However, th...
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Article
Cell regeneration and cyclic catalysis of engineered Kluyveromyces marxianus of a d-psicose-3-epimerase gene from Agrobacterium tumefaciens for d-allulose production
d-Allulose as a low-energy and special bioactive monosaccharide sugar is essential for human health. In this study, the d-psicose-3-epimerase gene (DPEase) of Agrobacterium tumefaciens was transferred into thermo...
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Article
Production of l-lactic acid by Rhizopus oryzae using semicontinuous fermentation in bioreactor
Semicontinuous fermentation using pellets of Rhizopus oryzae has been recognized as a promising technology for l-lactic acid production. In this work, semicontinuous fermentation of R. oryzae AS 3.819 for l-lacti...
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Article
Screening, breeding and metabolic modulating of a strain producing succinic acid with corn straw hydrolyte
Purpose In this paper, the high yield mutant strain was expected to be obtained for the industrial bioconversion of corn straw hydrolyte to succinic acid. Methods API biochemical reactions and 16S r RNA sequence ...
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Investigation on the Structural Requirements for Binding Integrin αIIbβ3
Since the discovery of the cell adhesion sequence Arg-Gly-Asp (RGD) in fibronectin [1], it has been shown that the RGD sequence serves as a binding site of many adhesion proteins to integrin receptors [2]. The...