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Article
Open AccessMap** nucleolus-associated chromatin interactions using nucleolus Hi-C reveals pattern of heterochromatin interactions
As the largest substructures in the nucleus, nucleoli are the sites of ribosome biogenesis. Increasing evidence indicates that nucleoli play a key role in the organization of 3D genome architecture, but system...
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Article
CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation
Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments, topologically associating domains and loops. The canonical CTCF-mediated loop extrusion model ...
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Article
Fabrication of CdS/Ti3C2/g-C3N4NS Z-scheme composites with enhanced visible light-driven photocatalytic activity
The Ti3C2 and g-C3N4NS were obtained first, and the CdS/Ti3C2/g-C3N4NS Z-scheme composites were prepared via a facile hydrothermal synthesis, and their photocatalytic properties were investigated. The g-C3N4NS wi...
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Protocol
Using Open Chromatin Enrichment and Network Hi-C (OCEAN-C) to Identify Open Chromatin Interactions
The open chromatin enrichment and network Hi-C (OCEAN-C) was developed not only for identifying large-scale chromatin structures, including topologically associated domains (TADs) and A/B compartments, but als...
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Article
Open AccessPCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions
Polycomb group (PcG) ring finger protein 6 (PCGF6), though known as a member of the transcription-repressing complexes, PcG, also has activation function in regulating pluripotency gene expression. However, th...
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Article
Open AccessOCEAN-C: map** hubs of open chromatin interactions across the genome reveals gene regulatory networks
We develop a method called open chromatin enrichment and network Hi-C (OCEAN-C) for antibody-independent map** of global open chromatin interactions. By integrating FAIRE-seq and Hi-C, OCEAN-C detects open c...
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Article
Open Access3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
The Hi-C method is widely used to study the functional roles of the three-dimensional (3D) architecture of genomes. Here, we integrate Hi-C, whole-genome sequencing (WGS) and RNA-seq to study the 3D genome arc...
