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Protocol
The Rosetta Stone Method
Analysis of amino acid sequences from different organisms often reveals cases in which two or more proteins encoded for separately in a genome also appear as fusions, either in the same genome or that of some ...
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Protocol
Phylogenetic Profiling
Phylogenetic profiles describe the presence or absence of a protein in a set of reference genomes. Similarity between profiles is an indicator of functional coupling between gene products: the greater the simi...
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Protocol
Estimating Protein Function Using Protein-Protein Relationships
Many newly identified gene products from completely sequenced genomes are difficult to characterize in the absence of sequence homology to known proteins. In such a scenario, the context of the proteins’ funct...