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    Protocol

    The Rosetta Stone Method

    Analysis of amino acid sequences from different organisms often reveals cases in which two or more proteins encoded for separately in a genome also appear as fusions, either in the same genome or that of some ...

    Shailesh V. Date in Bioinformatics (2008)

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    Protocol

    Phylogenetic Profiling

    Phylogenetic profiles describe the presence or absence of a protein in a set of reference genomes. Similarity between profiles is an indicator of functional coupling between gene products: the greater the simi...

    Shailesh V. Date, José M. Peregrín-Alvarez in Bioinformatics (2008)

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    Protocol

    Estimating Protein Function Using Protein-Protein Relationships

    Many newly identified gene products from completely sequenced genomes are difficult to characterize in the absence of sequence homology to known proteins. In such a scenario, the context of the proteins’ funct...

    Shailesh V. Date in Gene Function Analysis (2007)