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Article
Open AccessSynthase-selected sorting approach identifies a beta-lactone synthase in a nudibranch symbiotic bacterium
Nudibranchs comprise a group of > 6000 marine soft-bodied mollusk species known to use secondary metabolites (natural products) for chemical defense. The full diversity of these metabolites and whether symbiot...
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Article
Open AccessAnalysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome
In this report we describe the genomic sequence of guinea pig cytomegalovirus (GPCMV) assembled from a tissue culture-derived bacterial artificial chromosome clone, plasmid clones of viral restriction fragment...
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Protocol
The Rosetta Stone Method
Analysis of amino acid sequences from different organisms often reveals cases in which two or more proteins encoded for separately in a genome also appear as fusions, either in the same genome or that of some ...
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Protocol
Phylogenetic Profiling
Phylogenetic profiles describe the presence or absence of a protein in a set of reference genomes. Similarity between profiles is an indicator of functional coupling between gene products: the greater the simi...
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Protocol
Estimating Protein Function Using Protein-Protein Relationships
Many newly identified gene products from completely sequenced genomes are difficult to characterize in the absence of sequence homology to known proteins. In such a scenario, the context of the proteins’ funct...
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Article
Discovery of uncharacterized cellular systems by genome-wide analysis of functional linkages
We introduce a general computational method, applicable on a genome-wide scale, for the systematic discovery of uncharacterized cellular systems. Quantitative analysis of the coinheritance of pairs of genes am...
