13 Result(s)
within
Shahrzad Jalali
English
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Article
Open AccessEndoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer
Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II clinical trials identified clinical activity of Z-...
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Article
Open AccessT-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma
T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and p...
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Article
Characterization of immune exhaustion and suppression in the tumor microenvironment of splenic marginal zone lymphoma
The role of the tumor microenvironment (TME) and intratumoral T cells in splenic marginal zone lymphoma (sMZL) is largely unknown. In the present study, we evaluated 36 sMZL spleen specimens by single cell ana...
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Article
High-dimensional and single-cell transcriptome analysis of the tumor microenvironment in angioimmunoblastic T cell lymphoma (AITL)
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive lymphoid malignancy associated with a poor clinical prognosis. The AITL tumor microenvironment (TME) is unique, featuring a minority population of mal...
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Article
Open AccessSIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma
Signal regulatory protein-α (SIRPα) is a key member of the “do-not-eat-me” signaling pathway, but its biological role and clinical relevance in B-cell NHL is relatively unknown. Using biopsy specimens from fol...
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Article
Open AccessReverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma
Treatment with programmed death-1 (PD-1) blocking antibodies results in high overall response rates in refractory and relapsed classical Hodgkin lymphoma (cHL) patients, indicating that PD-1/PD-1 ligand intera...
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Chapter and Conference Paper
An Intelligent Traffic Management System Based on the Wi-Fi and Bluetooth Sensing and Data Clustering
This paper introduces an automated clustering solution that applies to Wi-Fi/Bluetooth sensing data for intelligent route planning and city traffic management. The solution is based on sensing Wi-Fi and Blueto...
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Article
Open AccessTherapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, includin...
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Article
The genomic landscape of schwannoma
Gelareh Zadeh, Kenneth Aldape and colleagues present an integrative genomic analysis of schwannomas. In addition to finding recurrent mutations in ARID1A, ARID1B and DDR1, they identify a recurrent SH3PXD2A-HTRA1
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Article
Open AccessProteins involved in regulating bone invasion in skull base meningiomas
Bone invasive skull base meningiomas are a subset of meningiomas that present a unique clinical challenge due to brain and neural structure involvement and limitations in complete surgical resection, resulting...
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Protocol
Growth Regulation of Nervous System Tumours: Models for Assessment of Angiogenesis in Brain Tumours
The metabolic demand of rapidly proliferating tumour cells is reliant on an adequate blood supply that allows the continual delivery of oxygen, nutrients and growth factors. The growth and progression of tumou...
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Article
Open AccessFocused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
The Blood Brain Barrier (BBB) maintains the homeostasis of central nervous system by preventing the free passage of macromolecules from the systemic circulation into the brain. This normal physiological functi...
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Article
Upregulation of the α1-adrenoceptor-induced phosphoinositide and inotropic response in hypothyroid rat heart
In this study, we examined changes in the biochemical and inotropic events of the α1-adrenoceptor signaling pathway in hypothyroid rat hearts. Hypothyroidism was induced by treating experimental animals with 0.05...
