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Article
Terpolymeric platform with enhanced hydrophilicity via cysteic acid for serum intact glycopeptide analysis
A new polymeric (methyl methacrylate/ethylene glycol dimethacrylate/1,2-epoxy-5-hexene) base/matrix has been fabricated and decorated with zwitterionic hydrophilic cysteic acid (Cya) for the enrichment of inta...
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Article
Iminodiacetic acid (IDA)-generated mesoporous nanopolymer: a template to relate surface area, hydrophilicity, and glycopeptides enrichment
A three-step strategy is introduced to develop inherent iminodiacetic (IDA)-functionalized nanopolymer. SEM micrographs show homogenous spherical beads with a particle size of 500 nm. Further modification to C...
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Drugs Resistance in Lungs Diseases
Asthma is projected to be the third cause of death in all communities without age, gender, or race limits, along with Chronic Obstructive Pulmonary Disease (COPD). Patients treated with inhaled corticosteroids...
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Article
Highly porous terpolymer-ZIF8@BA MOF composite for identification of mono- and multi-glycosylated peptides/proteins using MS-based bottom-up approach
A hydrophilic terpolymer MOF composite is designed with high surface area and porosity to enrich mono- and multi-glycosylated peptides facilitating a bottom-up approach. Terpolymer@ZIF-8 is synthesized using f...
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Article
Boronic acid functionalized MOFs as HILIC material for N-linked glycopeptide enrichment
Highly specific enrichment of N-linked glycopeptides from complex biological samples is crucial prior to mass spectrometric analysis. In this work, a hydrophilic metal–organic framework composite is prepared b...
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Article
Metal–organic framework-based affinity materials in proteomics
Metal–organic frameworks (MOFs) are an eminent addition to materials science research because of their versatile properties due to which their applications are wide spread in proteomics. They are used in vario...
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Article
Open Access“Risk factors of birth asphyxia”
Birth asphyxia is an insult to the fetus or newborn due to failure to breath or breathing poorly, leads to decrease oxygen perfusion to various organs. According to WHO, 4 million neonatal deaths occurred each...
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Article
Open AccessHarmful effects of shisha: literature review
Tobacco is a preventable cause of morbidity and mortality across the world. A recently infamous way of smoking tobacco is shisha. Shisha smoking is also known as water pipe, hookah and Narghile smoking. The pe...
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Article
Open AccessMagnetic Resonance Image findings of Spinal Tuberclosis at first presentation
Spinal tuberculosis presents in various pathological patterns. The clinical presentation and often the management depend on exact pathological findings. Objective of study was to evaluate the Pathology of spin...
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Article
Open AccessAssessment of pattern for consumption and awareness regarding energy drinks among medical students
Energy drink is a type of beverage which contains stimulant drugs chiefly caffeine and marketed as mental and physical stimulator. Coffee, tea, soft drinks and other caffeinated beverages are not considered as...
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Article
Open AccessFahr’s syndrome: literature review of current evidence
Fahr’s disease or Fahr’s syndrome is a rare, neurological disorder characterized by abnormal calcified deposits in basal ganglia and cerebral cortex. Calcified deposits are made up of calcium carbonate and cal...
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Article
Open AccessSpectrum of prostatic lesions
Prostate gland of male reproductive system is about the size of walnut and surrounds the urethra. Most frequently encountered diseases affecting prostate are Prostatitis, Benign prostatic hyperplasia and Prost...
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Article
Open AccessBcr-Abl tyrosine kinase inhibitors- current status
Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib ...
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Article
Open AccessCarcinogenesis of PIK3CA
PIK3CA is the most frequently mutated oncogene in human cancers. PIK3CA is phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha. It controls cell growth, proliferation, motility, survival, d...
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Article
Open AccessClinico- pathological profile of patients with breast diseases
To evaluate the spectrum of breast diseases and their association with presenting complains of patients.
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Article
Open AccessAssessment of gallstone predictor: comparative analysis of ultrasonographic and biochemical parameters
Gallstones represent a significant burden for health care systems worldwide and are one of the most common disorders presenting to emergency room. Ultrasonography, complete blood picture test and liver functio...
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Article
Open Accessc-Met inhibitors
c-Met is a receptor tyrosine kinase that encodes protein such as hepatocyte growth factor receptor (HGFR). Inappropriate activity of c-Met can cause wide variety of carcinomas. c-Met inhibitor are relatively n...
