5 Result(s)
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Article
A community effort to create standards for evaluating tumor subclonal reconstruction
Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogeneity to infer evolutionary dynamics. A growing number of studies have used these approaches to link cancer ev...
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Article
Genome-wide germline correlates of the epigenetic landscape of prostate cancer
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymo...
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Article
Open AccessCombining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection
The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-geno...
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Article
Open AccessGermline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of develo** prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, h...
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Article
Genomic hallmarks of localized, non-indolent prostate cancer
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences a...
