5 Result(s)
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Shabareesh Pidathala
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Article
Author Correction: Substrate and drug recognition mechanisms of SLC19A3
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Substrate and drug recognition mechanisms of SLC19A3
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Open AccessCryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms
Pannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues. In...
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Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2
Monoamine neurotransmitters such as dopamine and serotonin control important brain pathways, including movement, sleep, reward and mood1. Dysfunction of monoaminergic circuits has been implicated in various neuro...
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Article
Open AccessStructural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters
Norepinephrine is a biogenic amine neurotransmitter that has widespread effects on alertness, arousal and pain sensation. Consequently, blockers of norepinephrine uptake have served as vital tools to treat dep...
