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  1. No Access

    Article

    Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer

    Identification of pro-metastatic genomic alterations is urgently needed to help understand and prevent the fatal course of prostate cancer. Here, we found that the transcription factor EGR3, located at chromosome...

    Seung-Hyun Shin, Il** Kim, Jae Eun Lee, Mingyu Lee, Jong-Wan Park in Oncogene (2020)

  2. No Access

    Article

    Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells

    Oxygen is an indispensable element for cell survival and maintenance. Eukaryotic cells are equipped with a series of signaling pathways that cope with hypoxia. The dioxygenase factor inhibiting HIF (FIH) is an...

    Il** Kim, Seung-Hyun Shin, Jae Eun Lee, Jong-Wan Park in Oncogene (2019)

  3. No Access

    Article

    The E3 ligase C-CBL inhibits cancer cell migration by neddylating the proto-oncogene c-Src

    Neddylation is a cellular process that covalently conjugates substrate proteins with the small ubiquitin-like molecule NEDD8. As neddylation is required for fast turnover of proteins in proliferating cancer ce...

    Gun-Woo Lee, Jun Bum Park, Sung Yeon Park, Jieun Seo, Seung-Hyun Shin… in Oncogene (2018)

  4. No Access

    Article

    Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway

    During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of ...

    Peng **, Seung-Hyun Shin, Yang-Sook Chun, Hyun-Woo Shin, Yong Jae Shin… in Oncogene (2018)