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Article
Open AccessProtein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development
Chronic colonic inflammation is a feature of cancer and is strongly associated with tumorigenesis, but its underlying molecular mechanisms remain poorly understood. Inflammatory conditions increased ITF2 and p...
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Article
Open AccessA novel glucagon analog with an extended half-life, HM15136, normalizes glucose levels in rodent models of congenital hyperinsulinism
Congenital hyperinsulinism (CHI) is a rare genetic condition characterized by uncontrolled insulin secretion, resulting in hypoglycemia. Although glucagon has lately been regarded as a therapeutic option for C...
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Article
Extrauterine growth restriction in extremely preterm infants based on the Intergrowth-21st Project Preterm Postnatal Follow-up Study growth charts and the Fenton growth charts
Growth charts are essential for monitoring the postnatal growth of preterm infants. The preterm postnatal follow-up study (PPFS) of the Intergrowth-21st Project provides new growth standards based on a longitu...
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Article
Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer
Identification of pro-metastatic genomic alterations is urgently needed to help understand and prevent the fatal course of prostate cancer. Here, we found that the transcription factor EGR3, located at chromosome...
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Article
Fluid–Structure Interaction Based on Meshless Local Petrov–Galerkin Method for Worm Soft Robot Analysis
The purpose of this study was to develop a two-way fluid–structure interaction (FSI) method using the meshless local Petrov–Galerkin (MLPG) method for both the structure and the fluid to accurately predict the...
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Article
Open AccessThe Association of Pregnancy-induced Hypertension with Bronchopulmonary Dysplasia – A Retrospective Study Based on the Korean Neonatal Network database
The prevalence of pregnancy-induced hypertension (PIH) and preeclampsia (PE) are 5–10% and 2–4%, respectively. PIH might affect angiogenesis in preterm neonates, but its association with bronchopulmonary dyspl...
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Article
Open AccessEarly postnatal cardiac manifestations are associated with perinatal brain injury in preterm infants with twin to twin transfusion syndrome
Altered hemodynamics associated with twin to twin transfusion syndrome (TTTS) can be manifested in the fetal and neonatal heart. This study evaluated the association between cardiac manifestations immediately ...
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Article
Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells
Oxygen is an indispensable element for cell survival and maintenance. Eukaryotic cells are equipped with a series of signaling pathways that cope with hypoxia. The dioxygenase factor inhibiting HIF (FIH) is an...
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Article
Open AccessNuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2
The fibroblast growth factor receptor 2 (FGFR2) is a membrane receptor that promotes cell proliferation and differentiation. FGFR2 is also present in the nucleus, which raises a question on a new role of FGFR2...
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Article
Open AccessAberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
Despite many efforts to develop hormone therapy and chemotherapy, no effective strategy to suppress prostate cancer metastasis has been established because the metastasis is not well understood. We here invest...
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Article
Significantly-enhanced Stabilities in Flexible Hybrid Organic-Inorganic Perovskite Resistive Random Access Memories by Employing Multilayer Graphene Transparent Conductive Electrodes
Despite several reports on perovskite resistive random access memories (RRAMs), most of them are based on transparent conductive oxide electrodes, not suitable for high flexibility. We first employ multilayer-...
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Article
The E3 ligase C-CBL inhibits cancer cell migration by neddylating the proto-oncogene c-Src
Neddylation is a cellular process that covalently conjugates substrate proteins with the small ubiquitin-like molecule NEDD8. As neddylation is required for fast turnover of proteins in proliferating cancer ce...
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Article
Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway
During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of ...
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Article
Open AccessNDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors
Expression of hypoxia-inducible factors (HIFs) and N-myc downstream-regulated gene 3 (NDRG3) are oxygen-dependently regulated by prolyl hydroxylase domain (PHD) enzymes. Little is known about the role of NDRG3...
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Article
Baicalin, a flavonoid, affects the activity of human dermal papilla cells and promotes anagen induction in mice
Baicalin, a flavonoid isolated from Scutellaria baicalensis, is known to have multiple biological functions. Recent studies have demonstrated that baicalin treatment increases alkaline phosphatase activity (ALP) ...
