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Murine Mesenchymal Stem Cells Suppress T Lymphocyte Activation Through IL-2 Receptor α (CD25) Cleavage by Producing Matrix Metalloproteinases
Mesenchymal stem cells (MSCs) are multipotent, non-hematopoietic stem cells that exhibit the capacity to inhibit the proliferation of a variety of immune cells. However, the underlying mechanisms of the immuno...
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Article
Open AccessSoluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on T cel...