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  1. No Access

    Article

    Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain

    The Sigma-1 receptor (σ1R) is highly expressed in the primary sensory neurons (PSNs) that are the critical site of initiation and maintenance of pain following peripheral nerve injury. By immunoblot and immunohis...

    Seung Min Shin, Fei Wang, Chensheng Qiu, Brandon Itson-Zoske… in Gene Therapy (2022)

  2. No Access

    Article

    AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain

    Transmission of pain signals from primary sensory neurons to secondary neurons of the central nervous system is critically dependent on presynaptic voltage-gated calcium channels. Calcium channel-binding domai...

    Hongwei Yu, Seung Min Shin, Hongfei **ang, Dongman Chao, Yongsong Cai… in Gene Therapy (2019)

  3. No Access

    Article

    Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice

    Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastas...

    Jesang Ko, Seung Min Shin, Young Mi Oh, Youn Soo Lee, Zae Yoong Ryoo… in Oncogene (2004)

  4. No Access

    Article

    Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization

    Basic studies of oncogenesis have demonstrated that either the elevated production of particular oncogene proteins or the occurrence of qualitative abnormalities in oncogenes can contribute to neoplastic cellu...

    Jesang Ko, Young Han Lee, Seung Yong Hwang, Youn Soo Lee, Seung Min Shin… in Oncogene (2003)