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  1. Article

    Open Access

    Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

    Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3.2) regulates neuronal excitability and plays important r...

    Brandon Itson-Zoske, Seung Min Shin, Hao Xu, Chensheng Qiu… in Arthritis Research & Therapy (2022)

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    Article

    Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain

    The Sigma-1 receptor (σ1R) is highly expressed in the primary sensory neurons (PSNs) that are the critical site of initiation and maintenance of pain following peripheral nerve injury. By immunoblot and immunohis...

    Seung Min Shin, Fei Wang, Chensheng Qiu, Brandon Itson-Zoske… in Gene Therapy (2022)