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Article
Open AccessTranslatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
Somatic ribosomal protein mutations have recently been described in cancer, yet their impact on cellular transcription and translation remains poorly understood. Here, we integrate mRNA sequencing, ribosome fo...
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Article
Open AccessCorrection: The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
Following the publication of this article, the authors noted that Dr Laura Fancello was not listed among the authors. The corrected author list is given below. Additionally, the following was not included in t...
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Article
The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
The R98S mutation in ribosomal protein L10 (RPL10 R98S) affects 8% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases, and was previously described to impair cellular proliferation. The current stu...
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Article
Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway
Programmed −1 ribosomal frameshift (−1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in viruses, how these elements may regulate cellular gene...