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Living Reference Work Entry In depth
Position-Specific 13C Isotope Analysis by NMR as a Tool for Authentication of Ethanol-Containing Beverages
It was established that irm-13C NMR is a performant tool to study the 13C intramolecular distribution in ethanol and that is the efficient way to assess the position-specific isotope compositions in the parent ca...
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Living Reference Work Entry In depth
Position-Specific 13C Isotope Analysis by NMR as a Tool for Characterizing the Manufacturing Process Used and for Fighting Pharmaceutics Counterfeiting
Counterfeits based on deliberate copying of processes for generic medicines are not straightforward to detect. Multidimensional isotope profiling is a useful tool for the characterization of the provenance of ...
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Living Reference Work Entry In depth
Contribution of Position-Specific Isotope Analysis for Characterizing the Origin of Vanillin: Kee** One Step Ahead of the Fraudster
Authenticity and traceability of food products are of increasingly importance for consumers and regulatory instances. In such a context, vanillin is of considerable interest. Because of its organoleptic featur...
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Article
Open AccessSite-specific carbon isotope measurements of vanillin reference materials by nuclear magnetic resonance spectrometry
Vanillin, one of the world’s most popular flavor used in food and pharmaceutical industries, is extracted from vanilla beans or obtained (bio)-synthetically. The price of natural vanillin is considerably highe...
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Article
A precise and rapid isotopomic analysis of small quantities of cholesterol at natural abundance by optimized 1H-13C 2D NMR
Cholesterol, the principal zoosterol, is a key metabolite linked to several health complications. Studies have shown its potential as a metabolic biomarker for predicting various diseases and determining food ...
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Article
Open AccessConsequences of blunting the mevalonate pathway in cancer identified by a pluri-omics approach
We have previously shown that the combination of statins and taxanes was a powerful trigger of HGT-1 human gastric cancer cells’ apoptosis1. Importantly, several genes involved in the “Central carbon metabolism p...
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Reference Work Entry In depth
Isotope Ratio Monitoring by NMR: Part 3 – New Applications for Traceability of Active Pharmaceutical Ingredients
Isotopic ratio measurement by nuclear magnetic resonance (irm-NMR) is recognized as a powerful technique for assessing the traceability of active pharmaceutical ingredients (APIs). The results obtained with th...
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Reference Work Entry In depth
Isotope Ratio Monitoring by NMR: Part 1 – Recent Advances
Many physical and chemical processes in living systems are accompanied by isotopic fractionation on common atoms. The determination of isotopic abundance is therefore an unrivaled method to probe the (bio)chem...
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Living Reference Work Entry In depth
Isotope Ratio Monitoring by NMR. Part 3: New Applications for Traceability of Active Pharmaceutical Ingredients
Isotopic ratio measurement by nuclear magnetic resonance (irm-NMR) is recognized as a powerful technique for assessing the traceability of active pharmaceutical ingredients (APIs). The results obtained with th...
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Article
A strategy for simultaneous determination of fatty acid composition, fatty acid position, and position-specific isotope contents in triacylglycerol matrices by 13C-NMR
Triacylglycerols, which are quasi-universal components of food matrices, consist of complex mixtures of molecules. Their site-specific 13C content, their fatty acid profile, and their position on the glycerol moi...
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Living Reference Work Entry In depth
Isotope Ratio Monitoring by NMR. Part 1: Recent Advances
Many physical and chemical processes in living systems are accompanied by isotopic fractionation on common atoms. The determination of isotopic abundance is therefore an unrivaled method to probe the (bio)chem...
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Article
Comparative study of 13C composition in ethanol and bulk dry wine using isotope ratio monitoring by mass spectrometry and by nuclear magnetic resonance as an indicator of vine water status
The potential of wine 13C isotope composition (δ13C) is presented to assess vine water status during grape ripening. Measurements of δ13C have been performed on a set of 32 authentic wines and their ethanol recov...
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Article
Optimizing water suppression for quantitative NMR-based metabolomics: a tutorial review
In nuclear magnetic resonance (NMR)-based metabolomics, the water suppression scheme is one of the elements that most impact the overall quality of the spectrum. The choice of the solvent suppression scheme an...
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Article
How metabolomics can contribute to bio-processes: a proof of concept study for biomarkers discovery in the context of nitrogen-starved microalgae grown in photobioreactors
Microalgae appear to be one of the most promising sustainable resources as alternative crops for the production of renewable transport fuel. The exploitation of this bioresource requires, however, a fine monit...
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Article
In situ NMR spectroelectrochemistry for the structure elucidation of unstable intermediate metabolites
In situ NMR spectroelectrochemistry is presented in this study as a useful hybrid technique for the chemical structure elucidation of unstable intermediate species. An experimental setting was designed to foll...
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Article
Strategy for choosing extraction procedures for NMR-based metabolomic analysis of mammalian cells
Metabolomic analysis of mammalian cells can be applied across multiple fields including medicine and toxicology. It requires the acquisition of reproducible, robust, reliable, and homogeneous biological data s...
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Chapter
SNIF-NMR—Part 1: Principles
Applications of high resolution deuterium-NMR in organic and bioorganic chemistry have regularly expanded in the last decades, accompanying the development of high field spectrometers which are required to ove...
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Article
Traceability in quantitative NMR using an electronic signal as working standard
The choice of the reference, either as internal or external is not straightforward in quantitative NMR. In this context ERETIC™ methodology appears as an universal referencing technique. An electronic signal, ...
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Article
Quantitative assessment of metabolic changes during brain development with 1H Magnetic Resonance Spectroscopy (MRS) in vivo in two animal models † 957
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Article
QUANTITATIVE T2 MRI STUDY OF BRAIN INJURIES IN PRETERM INFANTS: CORRELATION WITH NEURODEVELOPMENTAL OUTCOME. † 1030