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Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning

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  1. Article

    Open Access

    CREB5 promotes the proliferation and self-renewal ability of glioma stem cells

    Glioblastoma multiforme (GBM) is the most fatal form of brain cancer in humans, with a dismal prognosis and a median overall survival rate of less than 15 months upon diagnosis. Glioma stem cells (GSCs), have ...

    Hyun-** Kim, Hye-Min Jeon, Don Carlo Batara, Seongsoo Lee in Cell Death Discovery (2024)

  2. Article

    Open Access

    Detection of intracellular monosodium urate crystals in gout synovial fluid using optical diffraction tomography

    Optical diffraction tomography (ODT) enables imaging of unlabeled intracellular components by measuring the three-dimensional (3D) refractive index (RI). We aimed to detect intracellular monosodium urate (MSU)...

    Sangwoo Park, Lucy Eunju Lee, Hanna Kim, Ji Eun Kim, Seung Jun Lee in Scientific Reports (2021)

  3. Article

    Open Access

    The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

    Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases, such as frontotemporal lobar degeneration with ...

    Shinrye Lee, Seyeon Kim, Ha-Young Kang, Hye Ryeong Lim in Journal of Neuroinflammation (2020)

  4. Article

    Open Access

    Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment

    Alzheimer’s disease (AD) is a neurodegenerative disease characterized by genotypic and phenotypic heterogeneity. Critical components of the two AD pathological pathways, Aβ-amyloidosis and Tauopathy, have been...

    Wenchao Sun, Seongsoo Lee, **aoran Huang, Song Liu in Scientific Reports (2016)

  5. Article

    Erratum to: Vision-Based Kidnap Recovery with SLAM for Home Cleaning Robots

    Seongsoo Lee, Sukhan Lee, Seungmin Baek in Journal of Intelligent & Robotic Systems (2015)