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Article
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma
Glioblastoma (GBM) is the most aggressive type of central nervous system tumor. Molecular targeting may be important when develo** efficient GBM treatment strategies. Sequencing of GBMs revealed that the rec...
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Article
Open AccessEfficacy of hydroxyapatite-based skull base reconstruction for intraoperative high-flow cerebrospinal fluid leakage performed by less-experienced surgeons
Cerebrospinal fluid (CSF) leakage after endoscopic skull base surgery remains a challenge despite multilayer reconstruction including nasoseptal flap (NSF) has become a standard technique. Injectable hydroxyap...
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Article
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases
Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial componen...
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Article
Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma
Phosphodiesterase 11A (PDE11A), a 3′,5′-cyclic nucleotide phosphodiesterase, is a key regulator of intracellular signaling that functions by degrading cyclic adenosine monophosphate (cAMP) and cyclic guanosine...
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Article
Open AccessEmerging role of LETM1/GRP78 axis in lung cancer
The selective autophagy of damaged mitochondria is called mitophagy. Mitochondrial dysfunction, mitophagy, and apoptosis have been suggested to be interrelated in various human lung carcinomas. Leucine zipper ...
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Article
Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma
Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (...
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Article
Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo
The development of skeletal muscle requires progression of a highly ordered cascade of events comprising myogenic lineage commitment, myoblast proliferation, and terminal differentiation. The process of myogen...
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Article
Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death
Lung cancer is the most common cause of cancer-associated death worldwide. Most patients with non-small cell lung cancer die within several years of the initial diagnosis, and new therapies are desperately nee...
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Article
Stent-Retriever Angioplasty for Recurrent Post-Subarachnoid Hemorrhagic Vasospasm – A Single Center Experience with Long-Term Follow-Up
We report our experience of using stent-retrievers for recurrent cerebral vasospasm (CVS) secondary to aneurysmal subarachnoid hemorrhage (aSAH).
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Article
Open AccessEmerging roles of TRIO and F-actin-binding protein in human diseases
TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP va...
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Article
Early Occurrence of Sinking Skin Flap Syndrome in a State of Intracranial Hypertension
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Article
Open AccessTMEM39A and Human Diseases: A Brief Review
Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM3...
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Article
Open AccessRecognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor
Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. How...
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Article
Open AccessTargeting Cancer Metabolism - Revisiting the Warburg Effects
After more than half of century since the Warburg effect was described, this atypical metabolism has been standing true for almost every type of cancer, exhibiting higher glycolysis and lactate metabolism and ...
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Article
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65
Constitutive NF-κB activation in cancer cells is caused by defects in the signalling network responsible for terminating the NF-κB response. Here we report that plant homeodomain finger protein 20 (PHF20) main...
