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Article
Open AccessSequential role of RAD51 paralog complexes in replication fork remodeling and restart
Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability, HR-mediated fork remodeling promotes cancer chemoresistance...
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Article
Open AccessClinical impact of the type VI secretion system on virulence of Campylobacter species during infection
The clinical course of Campylobacter infection varies in symptoms and severity depending on host factors, virulence of the pathogen and initiated therapy. The type VI secretion system (T6SS) has been identified a...
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Article
Open AccessReplication fork reversal triggers fork degradation in BRCA2-defective cells
Besides its role in homologous recombination, the tumor suppressor BRCA2 protects stalled replication forks from nucleolytic degradation. Defective fork stability contributes to chemotherapeutic sensitivity of BR...
