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  1. Article

    Open Access

    The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

    While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann… in BMC Cancer (2019)

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  2. No Access

    Article

    Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

    Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration map** (CESAM), which they use to identify somatic copy-number alterations affecting cis-regul...

    Joachim Weischenfeldt, Taronish Dubash, Alexandros P Drainas… in Nature Genetics (2017)