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  1. Article

    Open Access

    Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors

    Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...

    Sebastian M. Dieter, Domenica Lovecchio, Abhijeet Pataskar, Martina K. Zowada in Oncogene (2022)

  2. Article

    Open Access

    The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

    While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann in BMC Cancer (2019)