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Article

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...

Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter… in Genome Biology (2021)