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Article
The early years: hirschsprung disease and health-related quality of life
Chronic diseases are notorious in the way that they interfere with many aspects of a child’s development, and this holds true for children with Hirschsprung disease (HD). The present research aims to (1) deter...
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Article
Open AccessA systematic overview of rare disease patient registries: challenges in design, quality management, and maintenance
Patient registries serve to overcome the research limitations inherent in the study of rare diseases, where patient numbers are typically small. Despite the value of real-world data collected through registrie...
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Chapter
Constipation
Constipation is a common condition, with the reported prevalence in children ranging from 0.7 to 29.6%. The peak incidence of constipation occurs between 2 and 4 years of age, with an increased prevalence in b...
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Article
Preexisting neural factors that contribute to dysmotility in esophageal atresia: a systematic review
Esophageal dysmotility in esophageal atresia (EA) relates to abnormal development of esophageal innervation and musculature and to the esophageal repair. Few studies have investigated the preexisting dysmotili...
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Chapter
Anorectal Malformations
Anorectal malformations (formerly referred to as imperforate anus) are a class of congenital anomalies that are represented by a wide spectrum of defects, some relatively mild, some quite severe. Although the ...
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Article
Radiation burden in patients with esophageal atresia: a systematic review
Esophageal atresia (EA) is the most common congenital esophageal disorder. Radiological imaging facilitates diagnosis, surgical interventions, and follow-up. Despite this, standardized monitoring guidelines ar...
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Article
Selective approach to preoperative echocardiography in esophageal atresia
Preoperative echocardiography is used routinely in neonates with esophageal atresia to identify patients in whom congenital cardiac disease will impact upon anesthetic and surgical decision-making. We aimed to...
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Article
Open AccessEhlers–Danlos syndrome type IV: a case report of a rare cause of spontaneous sigmoid perforation and enteroatmospheric fistulae in a child
Ehlers–Danlos syndrome (EDS) type IV is a rare subtype of EDS, but has important surgical implications.
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Article
Constipation—Surgical Aspects, Investigations, and Therapies
The surgical management of pediatric constipation has been modified in recent years, with a more focused approach to operative interventions and colonic resection. This review will highlight recent insights in...
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Article
Duodeno-duodenostomy or duodeno-jejunostomy for duodenal atresia: is one repair better than the other?
The surgical management of neonates with duodenal atresia (DA) involves re-establishment of intestinal continuity, either by duodeno-duodenostomy (DD) or by duodeno-jejunostomy (DJ). Although the majority of p...
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Article
Nuclear transit study in children with chronic faecal soiling after Hirschsprung disease (HSCR) surgery has revealed a group with rapid proximal colonic treatment and possible adverse reactions to food
Long-term problems with faecal incontinence occur in up to 50 % of patients after pull-through for Hirschsprung disease (HSCR). The cause often remains unknown, leading to empirical treatments. Using nuclear t...
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Article
Gender differences in reduced substance P (SP) in children with slow-transit constipation
Adult slow-transit constipation (STC) occurs predominantly in females and is associated with low numbers of substance P (SP)-containing nerves in colonic circular muscle.
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Article
Gastrointestinal transit in children with chronic idiopathic constipation
Chronic constipation in children is common and produces significant morbidity. Identification of the site of dysmotility in constipation may determine the cause and permit directed management. Scintigraphy dif...
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Article
Slow-transit constipation in children: our experience
Constipation is a common problem in children, with childhood prevalence estimated at between 1 and 30%. It accounts for a significant percentage of referrals to paediatricians and paediatric gastroenterologist...
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Article
Reduced distribution of pacemaking cells in dilated colon
Interstitial cells of Cajal (ICC) act as pacemaker in gastrointestinal smooth muscle. In animals, small bowel dilatation produces a reduction in ICC numbers and in pacemaker function. With resolution of dilata...
