13 Result(s)
within
Se-Young Choi
Neurosciences
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Article
Open AccessThe ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens
Drug addiction therapies commonly fail because continued drug use promotes the release of excessive and pleasurable dopamine levels. Because the connection between pleasure and drug use becomes hard-wired in t...
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Author Correction: Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
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Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between e...
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Open AccessCorrection to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
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Open AccessAltered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice
Variants of the cytoplasmic FMR1-interacting protein (CYFIP) gene family, CYFIP1 and CYFIP2, are associated with numerous neurodevelopmental and neuropsychiatric disorders. According to several studies, CYFIP1 re...
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Open AccessReceptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses
Members of the leukocyte common antigen-related receptor protein tyrosine phosphatase (LAR-RPTP) family, comprising PTPσ, PTPδ and LAR, are key hubs for presynaptic assembly and differentiation in vertebrate n...
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Negr1 regulates hippocampal Lcn2 expression and affective behaviour via interaction with LIF receptor
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Negr1 controls adult hippocampal neurogenesis and affective behaviors
Recent genome-wide association studies on major depressive disorder have implicated neuronal growth regulator 1 (Negr1), a GPI-anchored cell adhesion molecule in the immunoglobulin LON family. Although Negr1 h...
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Two distinct mechanisms for experience-dependent homeostasis
Models of firing rate homeostasis such as synaptic scaling and the sliding synaptic plasticity modification threshold predict that decreasing neuronal activity (for example, by sensory deprivation) will enhanc...
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Polychlorinated biphenyl 19 blocks the most common form of store-operated Ca2+ entry through Orai
PCB19, a 2,2′,6-trichlorinated biphenyl, is one of many non-dioxin-like polychlorinated biphenyls (NDL-PCBs), which are ubiquitous pollutants. NDL-PCBs affect cytosolic Ca2+ signaling by promoting Ca2+ release fr...
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Cortisone and hydrocortisone inhibit human Kv1.3 activity in a non-genomic manner
Glucocorticoids are hormones released in response to stress that are involved in various physiological processes including immune functions. One immune-modulating mechanism is achieved by the Kv1.3 voltage-dep...
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Article
Open AccessChannel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
Activation of G protein coupled receptor (GPCR) in astrocytes leads to Ca2+-dependent glutamate release via Bestrophin 1 (Best1) channel. Whether receptor-mediated glutamate release from astrocytes can regulate s...
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Article
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
ADHD is characterized by hyperactivity and deficits in learning and memory. Now, Eunjoon Kim and colleagues report that a polymorphism in the gene that encodes the adaptor protein GIT1 is linked to ADHD in hum...
