The Analysis of Gene Expression Data
Methods and Software
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Open AccessA data quality assessment of the first four years of malaria reporting in the Senegal DHIS2, 2014–2017
As the global burden of malaria decreases, routine health information systems (RHIS) have become invaluable for monitoring progress towards elimination. The District Health Information System, version 2 (DHIS2...
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Open AccessSex-specific effects of aging on humoral immune responses to repeated influenza vaccination in older adults
Older adults (≥65 years of age) bear a significant burden of severe disease and mortality associated with influenza, despite relatively high annual vaccination coverage and substantial pre-existing immunity to...
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Open AccessPredicting clinical events using Bayesian multivariate linear mixed models with application to scleroderma
Scleroderma is a serious chronic autoimmune disease in which a patient’s disease state manifests in several irregularly spaced longitudinal measures of lung, heart, skin, and other organ systems. Threshold cro...
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Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
The plasma proteomic changes that precede the onset of dementia could yield insights into disease biology and highlight new biomarkers and avenues for intervention. We quantified 4,877 plasma proteins in nonde...
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Open AccessClinical risk prediction with random forests for survival, longitudinal, and multivariate (RF-SLAM) data analysis
Clinical research and medical practice can be advanced through the prediction of an individual’s health state, trajectory, and responses to treatments. However, the majority of current clinical risk prediction...
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Open AccessTwo Distinct Types of Sweat Profile in Healthy Subjects While Exercising at Constant Power Output Measured by a Wearable Sweat Sensor
Wearable sweat sensors have enabled real-time monitoring of sweat profiles (sweat concentration versus time) and could enable monitoring of electrolyte loss during exercise or for individuals working in extrem...
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Open AccessDesigns of two randomized, community-based trials to assess the impact of alternative cookstove installation on respiratory illness among young children and reproductive outcomes in rural Nepal
Acute lower respiratory infections (ALRI) are a leading cause of death among children. Low birthweight is prevalent in South Asia and associated with increased risks of mortality, and morbidity, high levels of...
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Johns Hopkins University Department of Biostatistics
The Johns Hopkins Department of Biostatistics was established in 1918, the first of its kind. This article provides an overview to its key personalities and traditions, and its accomplishments in research and ...
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Inter-rater reliability of manual muscle strength testing in ICU survivors and simulated patients
The goal of the paper is to determine inter-rater reliability of trained examiners performing standardized strength assessments using manual muscle testing (MMT).
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Book
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Chapter
The Analysis of Gene Expression Data: An Overview of Methods and Software
This chapter is a rough map of the book. It provides a concise overview of data-analytic tasks associated with microarray studies, pointers to chapters that can help perform these tasks, and connections with s...
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Chapter
Snomad: Biologist-Friendly Web Tools for the Standardization and NOrmalization of Microarray Data
The use of DNA microarrays and other gene expression analysis techniques throughout the biological sciences has put extremely large, complex datasets in the hands of biologists who, for the most part, are not ...
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Chapter
Statistical Testimony on Damages in Minnesota v. Tobacco Industry
In 1994, the state of Minnesota and Minnesota Blue Cross/Blue Shield filed suit in Minnesota District Court against Philip Morris, six other tobacco companies, and two tobacco trade groups (“Tobacco”) alleging...
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Adjusted variable plots for Cox's proportional hazards regression model
Adjusted variable plots are useful in linear regression for outlier detection and for qualitative evaluation of the fit of a model. In this paper, we extend adjusted variable plots to Cox's proportional hazard...
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Some recent developments for regression analysis of multivariate failure time data
Cox's seminal 1972 paper on regression methods for possibly censored failure time data popularized the use of time to an event as a primary response in prospective studies. But one key assumption of this and o...
