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Article
Open AccessVaccination against COVID-19 — risks and benefits in children
Countries in Europe and around the world have taken varying approaches to their policies on COVID-19 vaccination for children. The low risk of severe illness from COVID-19 means that even small risks from vacc...
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Article
Open AccessDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomi...
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Article
Open AccessParental concern for clinically vulnerable child during first 18 months of the COVID pandemic
The uncertainties surrounding the COVID-19 pandemic have been associated with increased parental concern. The aim of this study is to explore if this increased level of concern is associated with certain indiv...
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Article
Open AccessComparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves
We hypothesised that the clinical characteristics of hospitalised children and young people (CYP) with SARS-CoV-2 in the UK second wave (W2) would differ from the first wave (W1) due to the alpha variant (B.1....
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Article
Open AccessChanges in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between 2006 and 2018
Streptococcus pneumoniae continues to cause significant disease burden. Whilst pneumococcal conjugate vaccines (PCV) have substantially reduced this burden, serotype replacement partially negates this success due...
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Article
Open AccessImmune responses against SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO study
Patients with hematological malignancies are at increased risk of severe COVID-19 outcomes due to compromised immune responses, but the insights of these studies have been compromised due to intrinsic limitati...
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Article
Open AccessRSV: perspectives to strengthen the need for protection in all infants
Respiratory syncytial virus (RSV)—the most common viral cause of bronchiolitis—is a significant cause of serious illness among young children between the ages of 0–5 years and is especially concerning in the f...
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Article
Open AccessPaediatric research in the times of COVID-19
The COVID-19 pandemic poses many direct and indirect consequences for children’s health and associated research. Direct consequences include participation of children in COVID-19 research trials, pausing other...
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Article
Open AccessExperts’ opinion for improving global adolescent vaccination rates: a call to action
Worldwide, lifestyle and resource disparities among adolescents contribute to unmet health needs, which have crucial present and future public health implications for both adolescents and broader communities. ...
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Article
Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
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Article
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction.
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Article
Open AccessSafety and immunogenicity of a varicella vaccine without human serum albumin (HSA) versus a HSA-containing formulation administered in the second year of life: a phase III, double-blind, randomized study
A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous...
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Article
Open AccessSafety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP
We assessed a combination multi-stage malaria vaccine schedule in which RTS,S/AS01B was given concomitantly with viral vectors expressing multiple-epitope thrombospondin-related adhesion protein (ME-TRAP) in a...
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Article
Open AccessAssessment of novel vaccination regimens using viral vectored liver stage malaria vaccines encoding ME-TRAP
Heterologous prime-boost vaccination with viral vectors simian adenovirus 63 (ChAd63) and Modified Vaccinia Ankara (MVA) induces potent T cell and antibody responses in humans. The 8-week regimen demonstrates ...
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Article
Open AccessPneumococcal conjugate vaccine implementation in middle-income countries
Since 2000, the widespread adoption of pneumococcal conjugate vaccines (PCVs) has had a major impact in the prevention of pneumonia. Limited access to international financial support means some middle-income c...
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Chapter
Clostridium difficile in Children: A Review of Existing and Recently Uncovered Evidence
The clinical significance of the presence of Clostridium difficile in children’s faeces remains uncertain using current diagnostic procedures. Clostridium difficile is a relatively common finding in infants with ...
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Chapter
Purpura Fulminans
Purpura fulminans has many causes, both infectious and non-infectious.
It is a common clinical and histologic...
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Article
Platelet and soluble CD40L in meningococcal sepsis
To determine the influence of meningococcal sepsis on levels of platelet derived CD40L and on endothelial CD40 expression.
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Chapter and Conference Paper
HIV-1 Infection in Children: Current Practice and Future Predictions
This review will discuss the global epidemiology and clinical classification of HIV-1 in children, and the management and treatment principles in an industrialized economic setting. The epidemiology highlights...
