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Article
Open AccessA fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis
Sweat is an essential protection system for the body, but its failure can result in pathologic conditions, including several skin diseases, such as palmoplantar pustulosis (PPP). As reduced intraepidermal E-ca...
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Article
Olaparib-induced cutaneous vasculitis in a patient with recurrent ovarian cancer
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Article
Open AccessMorphology of subsurface cracks in glass-ceramics induced by Vickers indentation observed by synchrotron X-ray multiscale tomography
The characterization of subsurface cracks induced by indentation is a challenge for understanding contact damage, impact, wear, erosion, and abrasion of brittle materials, because the crack pattern observable ...
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Article
Open AccessHigh-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds
Morphological profiling is an omics-based approach for predicting intracellular targets of chemical compounds in which the dose-dependent morphological changes induced by the compound are systematically compar...
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Chapter and Conference Paper
Introducing Speaker Vectors for Child Speech Synthesis in Neural Vocoders
Speech synthesis and sound quality conversion technologies using neural networks have garnered attention in recent years. Neural vocoders can synthesize high-quality speech that is indistinguishable from human...
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Chapter
Cough and Allergic Diseases
Cough is an explosive expiratory maneuver that is reflexively or deliberately intended to clear the airways. It is one of the most common symptoms prompting physician visits. The distinction between acute and ...
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Article
A randomized controlled trial of a structured program combining aerobic and resistance exercise for adults with type 2 diabetes in Japan
We assessed the effect of supervised, combined aerobic and resistance exercise on diabetic parameters in Japanese patients with type 2 diabetes mellitus (T2DM).
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Chapter and Conference Paper
Voice Quality Change Due to the Amount of Training Data for Multi- and Target-Speaker WaveNet Vocoders
In recent years, with the development of deep learning, speech synthesis and voice conversion technologies using neural networks have been attracting attention. A WaveNet vocoder combines WaveNet and a vocoder...
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Article
Open AccessSuccessful outcomes of endoscopic lithotripsy in completely bedridden patients with symptomatic urinary calculi
Due to the aging population, the number of completely bedridden individuals is expected to increase, and such individuals are at high risk of develo** urinary calculi. This retrospective study included 32 co...
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Article
Open AccessModel-based Prediction of the Long-term Glucose-Lowering Effects of Ipragliflozin, a Selective Sodium–Glucose Cotransporter 2 (SGLT2) Inhibitor, in Patients with Type 2 Diabetes Mellitus
Sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors inhibit the reabsorption of glucose from the kidneys and increase urinary glucose excretion (UGE), thereby lowering the blood glucose concentration i...
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Chapter and Conference Paper
Generating Dialogue Sentences to Promote Critical Thinking
Conventional dialogue generating methods focus on generating fluent sentences in context, but insufficient consideration of speaker emotions. They often generate sentences with the same sentimental polarity of...
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Article
The significance of intraoperative renal pelvic urine and stone cultures for patients at a high risk of post-ureteroscopy systemic inflammatory response syndrome
We examined the renal pelvic urine culture (RPUC) and stone culture (SC) during ureteroscopy and evaluated their associations with postoperative systemic inflammatory response syndrome (SIRS). We prospectively...
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Article
Open AccessSafety of Ipragliflozin in Patients with Type 2 Diabetes Mellitus: Pooled Analysis of Phase II/III/IV Clinical Trials
Ipragliflozin is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM). The objective of this pooled analysis was to characterise the safety...
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Reference Work Entry In depth
Allergic Ocular Diseases
The ocular surface may exhibit a wide variety of immunologic responses resulting in inflammation of the conjunctiva and cornea. Diagnosis of allergic conjunctivitis is generally made by thorough history and ca...
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Living Reference Work Entry In depth
Allergic Ocular Diseases
The ocular surface may exhibit a wide variety of immunologic responses resulting in inflammation of the conjunctiva and cornea. Diagnosis of allergic conjunctivitis is generally made by thorough history and ca...
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Article
Open AccessKynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae
Kynurenic acid (KA) is a tryptophan (Trp) metabolite that is synthesised in a branch of kynurenine (KYN) pathway. KYN aminotransferase (KAT) catalyses deamination of KYN, yielding KA. Although KA synthesis is ...
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Article
Effects of ipragliflozin, a selective sodium–glucose co-transporter 2 inhibitor, on blood pressure in Japanese patients with type 2 diabetes mellitus: a pooled analysis of six randomized, placebo-controlled clinical trials
Our aim was to examine the effects of ipragliflozin, a selective sodium–glucose co-transporter 2 inhibitor, on blood pressure in Japanese patients with type 2 diabetes mellitus (T2DM). We conducted a pooled an...
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Article
Radiocaesium contamination of bamboo shoots in Fukushima and surrounding regions after the Fukushima nuclear accident
Radiocaesium contamination of bamboo shoots was characterised using food monitoring data from 2011 to 2015 in Fukushima and surrounding prefectures in Japan. Though 134Cs + 137Cs activity concentration data on ba...
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Article
Epigenetic inactivation of FAT4 contributes to gastric field cancerization
Gastric cancer (GC) is highly influenced by aberrant methylation, and accumulation of aberrant methylation in gastric mucosae produces an epigenetic field for cancerization. Nevertheless, the individual driver...
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Article
Open AccessStrontium-90 activity concentration in soil samples from the exclusion zone of the Fukushima daiichi nuclear power plant
The radioactive fission product 90Sr has a long biological half-life (˜18 y) in the human body. Due to its chemical similarity to calcium it accumulates in bones and irradiates the bone marrow, causing its high r...
