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Article
Open AccessAssociation of atmospheric temperature with out-of-hospital natural deaths occurrence before and during the COVID-19 pandemic in Osaka, Japan
In this study, we aimed to investigate the relationship between out-of-hospital natural death (OHND) and ambient temperature and examine the seriousness of the impact of the coronavirus disease-2019 (COVID-19)...
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Article
Asymptotic justification of maximum likelihood estimation for the proportional excess hazard model in analysis of cancer registry data
Population-based cancer registry studies are conducted to investigate the various cancer question and have important impacts on cancer control. In order to investigate cancer prognosis from cancer registry dat...
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Article
Open AccessThe usefulness of the total metabolic tumor volume for predicting the postoperative recurrence of thoracic esophageal squamous cell carcinoma
Induction or adjuvant therapies are not always beneficial for thoracic esophageal squamous cell carcinoma (ESCC) patients, and it is thus important to identify patients at high risk for postoperative ESCC recu...
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Article
Female Athlete Triad and Male Athlete Triad Syndrome Induced by Low Energy Availability: An Animal Model
Energy availability (EA) is defined the difference in energy intake and exercise energy expenditure. Reduction of EA (i.e. Low energy availability, LEA) often causes abnormalities of reproduction system and dr...
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Article
Association between respiratory and heart rate fluctuations and death occurrence in dying cancer patients: continuous measurement with a non-wearable monitor
The present study aimed to explore the association between impending death and continual changes in respiratory and heart rates measured using a non-wearable monitor every minute for the final 2 weeks of life ...
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Article
Predicting tumor response and prognosis to neoadjuvant chemotherapy in esophageal squamous cell carcinoma patients using PERCIST: a multicenter study in Japan
To investigate the usefulness of the positron emission tomography response criteria in solid tumors 1.0 (PERCIST1.0) for predicting tumor response to neoadjuvant chemotherapy and prognosis and determine whethe...
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Article
Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumor
Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysi...
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Article
Circulating tumor cells as a prognostic marker for efficacy in the randomized phase III JO21095 trial in Japanese patients with HER2-negative metastatic breast cancer
Prognostic effects of circulating tumor cells (CTCs) have been reported in metastatic breast cancer (MBC). However, few phase III trials have investigated the potential role of CTCs in treatment selection. We ...
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Article
Efficacy and safety of low-dose capecitabine plus docetaxel versus single-agent docetaxel in patients with anthracycline-pretreated HER2-negative metastatic breast cancer: results from the randomized phase III JO21095 trial
The randomized phase III JO21095 trial compared the efficacy and safety of low-dose capecitabine plus docetaxel combination therapy (XT) versus single-agent administration of docetaxel in anthracycline-pretrea...
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Chapter
Meta-Analysis of Prognostic Studies Evaluating Time-Dependent Diagnostic and Predictive Capacities of Biomarkers
Prognostic biomarker studies, which examine the between biomarkers and patients’ prognoses, have played important roles in clinical decision making. Since prognostic studies are often conducted with small sa...
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Chapter
The 1930s: Japan’s War with China and American Non-Recognition
The Manchurian Incident of 1931 created severe discord in relations between Japan and the US. The Japanese government allowed the actions of the Japanese armed forces in Manchuria to drag it down a course whic...
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Article
Open AccessAssociation of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients
The most common event responsible for resistance to first- and second-generation (1st and 2nd) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) is acquisition of T790M mutation. We exami...
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Article
The Preventive Effect of Calcium Supplementation on Weak Bones Caused by the Interaction of Exercise and Food Restriction in Young Female Rats During the Period from Acquiring Bone Mass to Maintaining Bone Mass
Increasing calcium (Ca) intake is important for female athletes with a risk of weak bone caused by inadequate food intake. The aim of the present study was to examine the preventive effect of Ca supplementatio...
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Article
The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats
There is a concern that the combination of exercise with food intake reduction has a risk of reducing bone strength and bone mass in young female athletes. We examined the influence of the interaction of vol...
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Article
Confirming the authenticity of the geographical origin of Naruto dried wakame Undaria pinnatifida using stable nitrogen isotope ratios
In aquatic ecosystems, the stable nitrogen isotope ratio (δ15N) of wakame is affected by the δ15N of its nitrogen source. Thus, the δ15N of wakame is thought to differ between those grown in different aquatic eco...
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Article
Influence of Food Restriction Combined with Voluntary Running on Bone Morphology and Strength in Male Rats
Athletes, in particular endurance athletes and dancers, are chronically exposed to a state of low energy availability due to insufficient dietary energy intake and massive exercise energy expenditure. Low ener...
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Article
Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysis
Previous studies have demonstrated that both gefitinib and erlotinib are markedly effective for the treatment of non-small-cell lung cancer (NSCLC) with somatic activating mutations of the epidermal growth fac...
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Article
Estimation of treatment effects based on possibly misspecified Cox regression
In randomized clinical trials, a treatment effect on a time-to-event endpoint is often estimated by the Cox proportional hazards model. The maximum partial likelihood estimator does not make sense if the propo...
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Article
Open AccessIdentification of B cell epitopes reactive to human papillomavirus type-16L1- derived peptides
Persistent infection of human papillomavirus (HPV) types 16 and 18 causes cervical cancer. To better understand immune responses to the prophylactic vaccine, HPV 16/18 L1 virus-like particles (HPV-VLPs), we in...
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Article
Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juice
Improvement of diagnostic accuracy for pancreatic cancer in pancreatic disease patients was investigated by examining the combination of three diagnostic methods, i.e., measurements of RCAS1 and CEA levels in ...
