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  1. No Access

    Article

    Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

    Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotoni...

    Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura… in Nature Immunology (2017)

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    Article

    Separate domains of AID are required for somatic hypermutation and class-switch recombination

    Activation-induced cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutation (SHM). Mutants with changes in the C-terminal region of AID retain SHM but lose CSR activ...

    Reiko Shinkura, Satomi Ito, Nasim A Begum, Hitoshi Nagaoka… in Nature Immunology (2004)

  3. No Access

    Article

    AID mutant analyses indicate requirement for class-switch-specific cofactors

    Activation-induced cytidine deaminase (AID) is the essential and sole B cell–specific factor required for class-switch recombination (CSR) and somatic hypermutation (SHM). However, it is not known how AID diff...

    Van-Thanh Ta, Hitoshi Nagaoka, Nadia Catalan, Anne Durandy… in Nature Immunology (2003)