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Article
Utility of human epidermal growth factor 2 heterogeneity as a prognostic factor in triple-negative breast cancer
In some cases of human epidermal growth factor 2 (HER2)-negative breast cancer, including triple-negative breast cancer, HER2 expression is sporadically and strongly upregulated, a condition known as HER2 heterog...
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Article
Open AccessInvestigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment
Alpha-2-glycoprotein 1, zinc-binding (ZAG), a secreted protein encoded by the AZGP1 gene, is structurally similar to HLA class I. Despite its presumed immunological function, little is known about its role in tum...
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Article
Open AccessCorrection: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment
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Article
Open AccessClinicopathological features, genetic alterations, and BRCA1 promoter methylation in Japanese male patients with breast cancer
Male breast cancer (MBC) is a rare cancer accounting for only 1% of all male cancers and is, therefore, poorly studied. We aimed to characterize the subtypes of MBC in Japanese patients based on genetic profil...
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Article
Open AccessExpression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment
Elucidating the unique immunoregulatory mechanisms in breast cancer microenvironment may help develop new therapeutic strategies. Some studies have suggested that hormone receptors also have immune regulatory ...
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Article
Open AccessPrognostic significance of microinvasion with ductal carcinoma in situ of the breast: a meta-analysis
Ductal carcinoma in situ (DCIS) associated with invasive carcinoma ≤ 1 mm in size is defined as DCIS with microinvasion (DCIS/microinvasion) rather than as invasive breast carcinoma. The number of patients wit...
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Article
Open AccessImmunological profiles of the breast cancer microenvironment represented by tumor-infiltrating lymphocytes and PD-L1 expression
Tumor-infiltrating lymphocytes (TILs) and programmed cell death 1 ligand 1 (PD-L1) are established prognostic and predictive biomarkers for certain breast cancer subsets. However, their association with the im...
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Article
Open AccessAssociation of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer
L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor metabolism and be associated with tumor proliferation. In invasive breast cancer, we clinicopathologically inve...
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Article
Open AccessPrognostic significance of receptor expression discordance between primary and recurrent breast cancers: a meta-analysis
This meta-analysis aimed to investigate whether receptor (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]) discordances between primary and recurrent bre...
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Article
Open AccessClinical benefit of treatment after trastuzumab emtansine for HER2-positive metastatic breast cancer: a real-world multi-centre cohort study in Japan (WJOG12519B)
Trastuzumab emtansine (T-DM1) treatment for human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer after taxane with trastuzumab and pertuzumab is standard therapy. However, treatmen...
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Article
Prospective observational study of chemotherapy-induced alopecia after sequential FEC + taxane and the effects of age in breast cancer patients
Chemotherapy-induced alopecia (CIA) is a common and quite distressing adverse effects of chemotherapy. There are few detailed observational studies of CIA or of the impact of age on CIA. We performed a prospec...
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Article
Open AccessPhase II study of sequential S-1 and cyclophosphamide therapy in patients with metastatic breast cancer
S-1 and cyclophosphamide (CPA) can be given orally, and their combination may have great potential for treating metastatic breast cancer (MBC). A phase I study of sequential S-1 and CPA therapy was conducted i...
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Article
Open AccessTargetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets
Invasive lobular carcinoma (ILC) accounts for 10–15% of primary breast cancers and is typically estrogen receptor alpha positive (ER+) and ERBB2 non-amplified. Somatic mutations in ERBB2/3 are emerging as a tract...
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Article
Open AccessElevated MMP9 expression in breast cancer is a predictor of shorter patient survival
MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion molecules and cytokines. This study aims to...
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Article
FDG uptake reflects breast cancer immunological features: the PD-L1 expression and degree of TILs in primary breast cancer
High F18-fluorodeoxyglucose (FDG) uptake has been reported to be a predictor of poor prognosis in patients with breast cancer. We investigated the relationship between FDG uptake and immunological factors, inc...
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Article
Open AccessMyxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer
Breast cancer (BC) is a disease with variable morphology, clinical behaviour and response to therapy. Identifying factors associated with the progression of early-stage BC can help understand the risk of metas...
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Article
Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer
The epithelial–mesenchymal transition (EMT) plays a key role in breast cancer progression and metastasis. Lipocalin 2 (LCN2) is involved in the regulation of EMT. The aim of this study was to investigate the c...
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Article
Open AccessPrognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer
KN motif and ankyrin repeat domains 1 (KANK1) plays an important role in cytoskeleton maintenance and contributes to the regulation of cell proliferation, adhesion and apoptosis. KANK1 is involved in progressi...
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Article
Open AccessThe prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild-type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explor...
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Article
Open AccessClinicopathological values of PD-L1 expression in HER2-positive breast cancer
Several ongoing clinical trials are investigating the use of immuno-targeting therapy with programmed cell death protein-1 and programmed death-ligand 1 (PD-L1) inhibitors for triple-negative breast cancer. Ho...
