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Article
What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme...
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Article
Molekulare Diagnostik des vitreoretinalen Lymphoms
Das primäre vitreoretinale Lymphom (PVRL) stellt einen Subtyp der intraokularen Lymphome bzw. der malignen Lymphome des Auges dar. Das PVRL gilt als Sonderform des primären diffusen großzelligen Lymphoms (DLBC...
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Article
Open AccessResistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic opportunities
Immune checkpoint therapies (ICT) can reinvigorate the effector functions of anti-tumour T cells, improving cancer patient outcomes. Anti-tumour T cells are initially formed during their first contact (priming...
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Article
Open AccessCorrection: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748
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Article
Open AccessSF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response
SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and lead to global disruption of canonical splicing. Through synthetic lethal drug screens, we identify that SF3B1 mutant (SF3B1
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Article
Open AccessPatient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy...
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Article
Ruthenium106 plaque brachytherapy for uveal leiomyoma: a new approach to treatment?
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Article
Open AccessConjunctival Lymphoma
Lymphoma of the conjunctiva is an ocular malignancy derived from clonal proliferation of lymphocytes. The majority of conjunctival lymphoma is extranodal marginal zone B-Cell lymphoma (EMZL), however diffuse l...
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Article
Open AccessThe 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms
The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within ...
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Article
Open AccessThe 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms
We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be pres...
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Chapter
Develo** Prognostic Tools for Estimating Risk of Metastatic Death and Non-Metastatic Death in Individuals with Choroidal Melanoma
Approximately 50% of all patients with choroidal melanoma develop metastatic disease after months or years of apparent good health following ocular treatment. We have developed mathematical models to estimate ...
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Application of Deep Learning Models in the Evaluation of Histopathology of Uveal Melanoma
Digital pathology is being increasingly implemented in basic and translational research, as well as in routine clinical care for diagnostics and prognostication. With the latter, it is essentially an additiona...
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Intraocular Lymphomas
Lymphoma is a malignant neoplasm derived from monoclonal proliferations of B- or T-lymphocytes and rarely, natural killer (NK) cells. Ophthalmic involvement is relatively rare and may involve the ocular adnexa...
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Chapter
Genetics of Uveal Melanoma
Uveal melanoma is a rare, aggressive intraocular malignant tumor, leading to metastatic disease in over 50% of patients with tumors located in the ciliary body or choroid. Genetic studies have identified chrom...
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Article
Open AccessCM-Path Molecular Diagnostics Forum—consensus statement on the development and implementation of molecular diagnostic tests in the United Kingdom
Pathology has evolved from a purely morphological description of cellular alterations in disease to our current ability to interrogate tissues with multiple ‘omics’ technologies. By utilising these techniques ...
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Chapter
Classification of Uveal Tumors
Tumors of the same class should share a unique combination of features, which distinguishes them from all other classes. Classification, therefore, is the process of defining different tumor classes and correl...
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Chapter
Diagnostic Techniques: Other Biopsy Techniques
Alternatives to fine-needle aspiration biopsy include vitreous cutter aspiration biopsy, incisional biopsy, and excisional biopsy. Vitreous cutter aspiration biopsy is performed with a 25- or 27-gauge vitreous...
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Uveal Melanoma: Molecular Pathology
Research into the molecular genetics of uveal melanomas (UM) has identified several predictors of metastatic disease as well as signaling pathways and molecules that can be targeted using systemic therapies. M...
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Uveal Melanoma: Prognostication Methods
Almost 50% of uveal melanoma (UM) patients develop metastatic disease, despite successful ocular treatment. Metastases usually involve the liver and only rarely respond to treatment so that most patients die w...
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Chapter
Uveal Lymphoproliferative Tumors
Lymphoid proliferations of the uvea can be divided into two main groups: (a) primary uveal tumors and (b) secondary intraocular manifestations of systemic lymphoma. Although the exact frequency of the latter i...
