3 Result(s)
within
Sang R. Lee
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessProgesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration
Obesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since he...
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Article
Open AccessProgesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin
Hepatic gluconeogenesis is the main pathway for blood glucose maintenance activated during fasting. Retardation of insulin action, such as in diabetes mellitus, activates gluconeogenesis during the fed state. ...
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Article
Open AccessLoss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis
Non-alcoholic fatty liver disease (NAFLD) results from triglyceride accumulation within the liver and some of them advances to non-alcoholic steatohepatitis (NASH). It is important to note that in NAFLD develo...
