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Article
Predicting 30-day mortality after surgery for metastatic disease of the spine: the H2-FAILS score
Scoring systems for metastatic spine disease focus on predicting long- to medium-term mortality or a combination of perioperative morbidity and mortality. However, accurate prediction of perioperative mortalit...
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Article
Open AccessS-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner
S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model. Interestingly, S-SCAM Tg mice show male-...
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Article
Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study
High dimensional neuroimaging datasets and machine learning have been used to estimate and predict domain-specific cognition, but comparisons with simpler models composed of easy-to-measure variables are limit...
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Article
Open AccessAberrant expression of S-SCAM causes the loss of GABAergic synapses in hippocampal neurons
The duplication and deletion mutations of the S-SCAM/MAGI-2 gene are associated with schizophrenia and infantile spasms, respectively. S-SCAM is a unique synaptic scaffolding protein that localizes to both excita...
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Article
Open AccessPatient-specific cranio-spinal compliance distribution using lumped-parameter model: its relation with ICP over a wide age range
The distribution of cranio-spinal compliance (CSC) in the brain and spinal cord is a fundamental question, as it would determine the overall role of the compartments in modulating ICP in healthy and diseased s...
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Article
Open AccessReciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
Secreted Wnts play crucial roles in synaptogenesis and synapse maintenance, but endogenous factors promoting synapse elimination in central neurons remain unknown. Here we show that proline-rich 7 (PRR7) induc...
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Article
Open AccessInter-individual variation in genes governing human hippocampal progenitor differentiation in vitro is associated with hippocampal volume in adulthood
Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor...
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Article
Open AccessOttogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale express...
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Article
Large seasonal variation in phytoplankton production in the Amundsen Sea
To better estimate annual primary production in the Amundsen Sea, which is one of the highest productivity regions in the Southern Ocean, the seasonal variations in carbon and nitrogen uptake rates of phytopla...
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Article
Macromolecular production of phytoplankton in the northern Bering Sea, 2007
Photosynthetic carbon allocations into different macromolecular classes provide important clues regarding physiological conditions of phytoplankton and the nutritional status of potential grazers. The producti...
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Chapter
Biodiversity and Biogeography of the Lower Trophic Taxa of the Pacific Arctic Region: Sensitivities to Climate Change
The lower trophic level taxa underpin the marine ecosystems of the Pacific Arctic Region (PAR). Recent field observations indicate that range shifts, and changes in the relative abundance of particular taxa ha...
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Chapter
Progress and Challenges in Biogeochemical Modeling of the Pacific Arctic Region
At this early stage of modeling marine ecosystems and biogeochemical cycles in the Pacific Arctic Region (PAR), numerous challenges lie ahead. Observational data used for model development and validation remai...
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Article
Spatial distribution of small phytoplankton composition in the Chukchi Sea
This study was conducted as part of the second Russian American long-term census of the Arctic in 2009 with sampling across the territorial of the Russian Federation in the Chukchi Sea since recent information...
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Chapter
Carbon Biogeochemistry of the Western Arctic: Primary Production, Carbon Export and the Controls on Ocean Acidification
The Arctic Ocean is an important sink for atmospheric carbon dioxide (CO2) with a recent estimate suggesting that the region accounts for as much as 15 % of the global uptake of CO2. The western Arctic Ocean, in ...
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Article
Magnetic resonance imaging finding of empty sella in obesity related idiopathic intracranial hypertension is associated with enlarged sella turcica
Empty sella in MRI is an important finding associated with idiopathic intracranial hypertension (IIH). This study assesses the sensitivity and reproducibility of several morphological measures of the sella and...
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Article
Phylogenetic diversity of planktonic bacteria in the Chukchi Borderland region in summer
Planktonic bacteria are abundant in the Chukchi Borderland region. However, little is known about their diversity and the roles of various bacteria in the ocean. Seawater samples were collected from two statio...
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Article
Bacterioplankton community structure in the Arctic waters as revealed by pyrosequencing of 16S rRNA genes
Fjords and open oceans are two typical marine ecosystems in the Arctic region, where glacial meltwater and sea ice meltwater have great effects on the bacterioplankton community structure during the summer sea...
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Article
GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
Ubiquitin proteasome system–mediated, neuronal activity–dependent protein turnover at synapses often occurs in an ensemble fashion where a group or groups of postsynaptic density (PSD) proteins are degraded to...
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Article
Tracing offshore low-salinity plumes in the Northeastern Gulf of Mexico during the summer season by use of multispectral remote-sensing data
To trace offshore surface low-salinity water (LSW) in the northeastern Gulf of Mexico, a proxy was developed using the surface water beam attenuation coefficient (c p), and salinity matched with s...
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Article
Phytoplankton productivity and its response to higher light levels in the Canada Basin
Phytoplankton productivity in the Canada Basin was measured in the late summer season, from mid-September to mid-October 2009, using a 13C–15N dual tracer technique. To understand potential production changes ass...
